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Page 1
Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC. Mullarky E, et al. Among authors: lairson ll. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831078 Free PMC article.
RECOVER identifies synergistic drug combinations in vitro through sequential model optimization.
Bertin P, Rector-Brooks J, Sharma D, Gaudelet T, Anighoro A, Gross T, Martínez-Peña F, Tang EL, Suraj MS, Regep C, Hayter JBR, Korablyov M, Valiante N, van der Sloot A, Tyers M, Roberts CES, Bronstein MM, Lairson LL, Taylor-King JP, Bengio Y. Bertin P, et al. Among authors: lairson ll. Cell Rep Methods. 2023 Oct 23;3(10):100599. doi: 10.1016/j.crmeth.2023.100599. Epub 2023 Oct 4. Cell Rep Methods. 2023. PMID: 37797618 Free PMC article.
Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas.
Kuburich NA, den Hollander P, Castaneda M, Pietilä M, Tang X, Batra H, Martínez-Peña F, Visal TH, Zhou T, Demestichas BR, Dontula RV, Liu JY, Maddela JJ, Padmanabhan RS, Phi LTH, Rosolen MJ, Sabapathy T, Kumar D, Giancotti FG, Lairson LL, Raso MG, Soundararajan R, Mani SA. Kuburich NA, et al. Among authors: lairson ll. Cell Rep. 2023 Dec 26;42(12):113470. doi: 10.1016/j.celrep.2023.113470. Epub 2023 Nov 20. Cell Rep. 2023. PMID: 37979166 Free PMC article.
Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.
Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, Jaenisch R. Lyssiotis CA, et al. Among authors: lairson ll. Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. doi: 10.1073/pnas.0903860106. Epub 2009 May 15. Proc Natl Acad Sci U S A. 2009. PMID: 19447925 Free PMC article.
A small molecule accelerates neuronal differentiation in the adult rat.
Wurdak H, Zhu S, Min KH, Aimone L, Lairson LL, Watson J, Chopiuk G, Demas J, Charette B, Halder R, Weerapana E, Cravatt BF, Cline HT, Peters EC, Zhang J, Walker JR, Wu C, Chang J, Tuntland T, Cho CY, Schultz PG. Wurdak H, et al. Among authors: lairson ll. Proc Natl Acad Sci U S A. 2010 Sep 21;107(38):16542-7. doi: 10.1073/pnas.1010300107. Epub 2010 Sep 7. Proc Natl Acad Sci U S A. 2010. PMID: 20823227 Free PMC article.
Chemical control of stem cell fate and developmental potential.
Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG. Lyssiotis CA, et al. Among authors: lairson ll. Angew Chem Int Ed Engl. 2011 Jan 3;50(1):200-42. doi: 10.1002/anie.201004284. Angew Chem Int Ed Engl. 2011. PMID: 21184400 Review.
Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.
Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R, Schultz PG. Staerk J, et al. Among authors: lairson ll. Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5734-6. doi: 10.1002/anie.201101042. Epub 2011 May 5. Angew Chem Int Ed Engl. 2011. PMID: 21547985 Free PMC article. No abstract available.
Small molecule-based approaches to adult stem cell therapies.
Lairson LL, Lyssiotis CA, Zhu S, Schultz PG. Lairson LL, et al. Annu Rev Pharmacol Toxicol. 2013;53:107-25. doi: 10.1146/annurev-pharmtox-011112-140300. Annu Rev Pharmacol Toxicol. 2013. PMID: 23294307 Review.
A regenerative approach to the treatment of multiple sclerosis.
Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL. Deshmukh VA, et al. Among authors: lairson ll. Nature. 2013 Oct 17;502(7471):327-332. doi: 10.1038/nature12647. Epub 2013 Oct 9. Nature. 2013. PMID: 24107995 Free PMC article.
67 results