Heyen JR - Search Results

1

Validation and utility of the PhysioTel™ Digital M11 telemetry implant for cardiovascular data evaluation in cynomolgus monkeys and Beagle dogs.

Cordes JS, Heyen JR, Volberg ML, Poy N, Kreuser S, Shoieb AM, Steidl-Nichols J. Cordes JS, et al. Among authors: heyen jr. J Pharmacol Toxicol Methods. 2016 May-Jun;79:72-9. doi: 10.1016/j.vascn.2016.01.006. Epub 2016 Feb 1. J Pharmacol Toxicol Methods. 2016. PMID: 26844408

2

Sunitinib, a receptor tyrosine kinase inhibitor, increases blood pressure in rats without associated changes in cardiac structure and function.

Blasi E, Heyen J, Patyna S, Hemkens M, Ramirez D, John-Baptiste A, Steidl-Nichols J, McHarg A. Blasi E, et al. Cardiovasc Ther. 2012 Oct;30(5):287-94. doi: 10.1111/j.1755-5922.2011.00278.x. Epub 2011 May 31. Cardiovasc Ther. 2012. PMID: 21884012 Free article.

3

Mechanistic investigation of imatinib-induced cardiac toxicity and the involvement of c-Abl kinase.

Hu W, Lu S, McAlpine I, Jamieson JD, Lee DU, Marroquin LD, Heyen JR, Jessen BA. Hu W, et al. Among authors: heyen jr. Toxicol Sci. 2012 Sep;129(1):188-99. doi: 10.1093/toxsci/kfs192. Epub 2012 May 28. Toxicol Sci. 2012. PMID: 22641616

4

Cardiovascular differentiation of imatinib and bosutinib in the rat.

Heyen JR, Hu W, Jamieson J, Thibault S, Batugo M, Loi CM, Burns-Naas LA, McHarg AD, Jessen B. Heyen JR, et al. Int J Hematol. 2013 Nov;98(5):597-607. doi: 10.1007/s12185-013-1453-2. Epub 2013 Oct 19. Int J Hematol. 2013. PMID: 24142766

5

Characterization, biomarkers, and reversibility of a monoclonal antibody-induced immune complex disease in cynomolgus monkeys (Macaca fascicularis).

Heyen JR, Rojko J, Evans M, Brown TP, Bobrowski WF, Vitsky A, Dalton S, Tripathi N, Bollini SS, Johnson T, Lin JC, Khan N, Han B. Heyen JR, et al. Toxicol Pathol. 2014 Jun;42(4):765-73. doi: 10.1177/0192623314522559. Epub 2014 Mar 10. Toxicol Pathol. 2014. PMID: 24616262

6

Effects of chronic PPAR-agonist treatment on cardiac structure and function, blood pressure, and kidney in healthy sprague-dawley rats.

Blasi ER, Heyen J, Hemkens M, McHarg A, Ecelbarger CM, Tiwari S. Blasi ER, et al. PPAR Res. 2009;2009:237865. doi: 10.1155/2009/237865. Epub 2009 Jun 11. PPAR Res. 2009. PMID: 19536351 Free PMC article.

7

Cardiovascular effects in rats following exposure to a receptor tyrosine kinase inhibitor.

Aguirre SA, Heyen JR, Collette W 3rd, Bobrowski W, Blasi ER. Aguirre SA, et al. Among authors: heyen jr. Toxicol Pathol. 2010 Apr;38(3):416-28. doi: 10.1177/0192623310364027. Epub 2010 Mar 15. Toxicol Pathol. 2010. PMID: 20231546

8

Pan-FGFR inhibition leads to blockade of FGF23 signaling, soft tissue mineralization, and cardiovascular dysfunction.

Yanochko GM, Vitsky A, Heyen JR, Hirakawa B, Lam JL, May J, Nichols T, Sace F, Trajkovic D, Blasi E. Yanochko GM, et al. Among authors: heyen jr. Toxicol Sci. 2013 Oct;135(2):451-64. doi: 10.1093/toxsci/kft161. Epub 2013 Jul 20. Toxicol Sci. 2013. PMID: 23872713

9

Time course of AQP-2 and ENaC regulation in the kidney in response to PPAR agonists associated with marked edema in rats.

Tiwari S, Blasi ER, Heyen JR, McHarg AD, Ecelbarger CM. Tiwari S, et al. Among authors: heyen jr. Pharmacol Res. 2008 May;57(5):383-92. doi: 10.1016/j.phrs.2008.03.013. Epub 2008 Apr 7. Pharmacol Res. 2008. PMID: 18468451

10

Antisense inhibition of S6 kinase 1 produces improved glucose tolerance and is well tolerated for 4 weeks of treatment in rats.

Younis HS, Hirakawa B, Scott W, Tran P, Bhat G, Affolter T, Chapman J, Heyen J, Chakravarty K, Alton G. Younis HS, et al. Pharmacology. 2011;87(1-2):11-23. doi: 10.1159/000322526. Epub 2010 Dec 20. Pharmacology. 2011. PMID: 21178385

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