Pye CR - Search Results

1

A Strategy for Direct Chemical Activation of the Retinoblastoma Protein.

Pye CR, Bray WM, Brown ER, Burke JR, Lokey RS, Rubin SM. Pye CR, et al. ACS Chem Biol. 2016 May 20;11(5):1192-7. doi: 10.1021/acschembio.6b00011. Epub 2016 Feb 11. ACS Chem Biol. 2016. PMID: 26845289 Free PMC article.

2

Revisiting N-to-O acyl shift for synthesis of natural product-like cyclic depsipeptides.

Schwochert J, Pye C, Ahlbach C, Abdollahian Y, Farley K, Khunte B, Limberakis C, Kalgutkar AS, Eng H, Shapiro MJ, Mathiowetz AM, Price DA, Liras S, Lokey RS. Schwochert J, et al. Org Lett. 2014 Dec 5;16(23):6088-91. doi: 10.1021/ol503170b. Epub 2014 Nov 20. Org Lett. 2014. PMID: 25412436

3

Cell-permeable cyclic peptides from synthetic libraries inspired by natural products.

Hewitt WM, Leung SS, Pye CR, Ponkey AR, Bednarek M, Jacobson MP, Lokey RS. Hewitt WM, et al. Among authors: pye cr. J Am Chem Soc. 2015 Jan 21;137(2):715-21. doi: 10.1021/ja508766b. Epub 2015 Jan 8. J Am Chem Soc. 2015. PMID: 25517352

4

Probing the Physicochemical Boundaries of Cell Permeability and Oral Bioavailability in Lipophilic Macrocycles Inspired by Natural Products.

Bockus AT, Lexa KW, Pye CR, Kalgutkar AS, Gardner JW, Hund KC, Hewitt WM, Schwochert JA, Glassey E, Price DA, Mathiowetz AM, Liras S, Jacobson MP, Lokey RS. Bockus AT, et al. Among authors: pye cr. J Med Chem. 2015 Jun 11;58(11):4581-9. doi: 10.1021/acs.jmedchem.5b00128. Epub 2015 May 20. J Med Chem. 2015. PMID: 25950816

5

Going Out on a Limb: Delineating The Effects of β-Branching, N-Methylation, and Side Chain Size on the Passive Permeability, Solubility, and Flexibility of Sanguinamide A Analogues.

Bockus AT, Schwochert JA, Pye CR, Townsend CE, Sok V, Bednarek MA, Lokey RS. Bockus AT, et al. Among authors: pye cr. J Med Chem. 2015 Sep 24;58(18):7409-18. doi: 10.1021/acs.jmedchem.5b00919. Epub 2015 Sep 2. J Med Chem. 2015. PMID: 26308180

6

Stereochemistry Balances Cell Permeability and Solubility in the Naturally Derived Phepropeptin Cyclic Peptides.

Schwochert J, Lao Y, Pye CR, Naylor MR, Desai PV, Gonzalez Valcarcel IC, Barrett JA, Sawada G, Blanco MJ, Lokey RS. Schwochert J, et al. Among authors: pye cr. ACS Med Chem Lett. 2016 Jun 6;7(8):757-61. doi: 10.1021/acsmedchemlett.6b00100. eCollection 2016 Aug 11. ACS Med Chem Lett. 2016. PMID: 27563399 Free PMC article.

7

Passive Membrane Permeability in Cyclic Peptomer Scaffolds Is Robust to Extensive Variation in Side Chain Functionality and Backbone Geometry.

Furukawa A, Townsend CE, Schwochert J, Pye CR, Bednarek MA, Lokey RS. Furukawa A, et al. Among authors: pye cr. J Med Chem. 2016 Oct 27;59(20):9503-9512. doi: 10.1021/acs.jmedchem.6b01246. Epub 2016 Oct 11. J Med Chem. 2016. PMID: 27690434

8

Nonclassical Size Dependence of Permeation Defines Bounds for Passive Adsorption of Large Drug Molecules.

Pye CR, Hewitt WM, Schwochert J, Haddad TD, Townsend CE, Etienne L, Lao Y, Limberakis C, Furukawa A, Mathiowetz AM, Price DA, Liras S, Lokey RS. Pye CR, et al. J Med Chem. 2017 Mar 9;60(5):1665-1672. doi: 10.1021/acs.jmedchem.6b01483. Epub 2017 Jan 25. J Med Chem. 2017. PMID: 28059508 Free PMC article.

9

Retrospective analysis of natural products provides insights for future discovery trends.

Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Pye CR, et al. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5601-5606. doi: 10.1073/pnas.1614680114. Epub 2017 May 1. Proc Natl Acad Sci U S A. 2017. PMID: 28461474 Free PMC article.

10

Reply to Skinnider and Magarvey: Rates of novel natural product discovery remain high.

Pye CR, Bertin MJ, Lokey RS, Gerwick WH, Linington RG. Pye CR, et al. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):E6273. doi: 10.1073/pnas.1711139114. Epub 2017 Jul 14. Proc Natl Acad Sci U S A. 2017. PMID: 28710331 Free PMC article. No abstract available.

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