Linch DC - Search Results

1

The value of molecular stratification for CEBPA(DM) and NPM1(MUT) FLT3(WT) genotypes in older patients with acute myeloid leukaemia.

Dickson GJ, Bustraan S, Hills RK, Ali A, Goldstone AH, Burnett AK, Linch DC, Gale RE. Dickson GJ, et al. Among authors: linch dc. Br J Haematol. 2016 Feb;172(4):573-80. doi: 10.1111/bjh.13873. Epub 2015 Dec 21. Br J Haematol. 2016. PMID: 26847745 Free PMC article.

2

Long-term follow-up of granulocyte colony-stimulating factor receptor mutations in patients with severe congenital neutropenia: implications for leukaemogenesis and therapy.

Ancliff PJ, Gale RE, Liesner R, Hann I, Linch DC. Ancliff PJ, et al. Among authors: linch dc. Br J Haematol. 2003 Feb;120(4):685-90. doi: 10.1046/j.1365-2141.2003.04160.x. Br J Haematol. 2003. PMID: 12588357 Free article.

3

Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia.

Kottaridis PD, Gale RE, Linch DC. Kottaridis PD, et al. Among authors: linch dc. Leuk Lymphoma. 2003 Jun;44(6):905-13. doi: 10.1080/1042819031000067503. Leuk Lymphoma. 2003. PMID: 12854887 Review.

4

Flt3 mutations and leukaemia.

Kottaridis PD, Gale RE, Linch DC. Kottaridis PD, et al. Among authors: linch dc. Br J Haematol. 2003 Aug;122(4):523-38. doi: 10.1046/j.1365-2141.2003.04500.x. Br J Haematol. 2003. PMID: 12899708 Free article. Review. No abstract available.

5

No evidence that FLT3 status should be considered as an indicator for transplantation in acute myeloid leukemia (AML): an analysis of 1135 patients, excluding acute promyelocytic leukemia, from the UK MRC AML10 and 12 trials.

Gale RE, Hills R, Kottaridis PD, Srirangan S, Wheatley K, Burnett AK, Linch DC. Gale RE, et al. Among authors: linch dc. Blood. 2005 Nov 15;106(10):3658-65. doi: 10.1182/blood-2005-03-1323. Epub 2005 Aug 2. Blood. 2005. PMID: 16076872 Free article.

6

FLT3 tyrosine kinase domain mutations are biologically distinct from and have a significantly more favorable prognosis than FLT3 internal tandem duplications in patients with acute myeloid leukemia.

Mead AJ, Linch DC, Hills RK, Wheatley K, Burnett AK, Gale RE. Mead AJ, et al. Among authors: linch dc. Blood. 2007 Aug 15;110(4):1262-70. doi: 10.1182/blood-2006-04-015826. Epub 2007 Apr 24. Blood. 2007. PMID: 17456725 Free article.

7

The impact of FLT3 internal tandem duplication mutant level, number, size, and interaction with NPM1 mutations in a large cohort of young adult patients with acute myeloid leukemia.

Gale RE, Green C, Allen C, Mead AJ, Burnett AK, Hills RK, Linch DC; Medical Research Council Adult Leukaemia Working Party. Gale RE, et al. Among authors: linch dc. Blood. 2008 Mar 1;111(5):2776-84. doi: 10.1182/blood-2007-08-109090. Epub 2007 Oct 23. Blood. 2008. PMID: 17957027 Free article.

8

Acute myeloid leukaemia blast cells with a tyrosine kinase domain mutation of FLT3 are less sensitive to lestaurtinib than those with a FLT3 internal tandem duplication.

Mead AJ, Gale RE, Kottaridis PD, Matsuda S, Khwaja A, Linch DC. Mead AJ, et al. Among authors: linch dc. Br J Haematol. 2008 May;141(4):454-60. doi: 10.1111/j.1365-2141.2008.07025.x. Epub 2008 Mar 12. Br J Haematol. 2008. PMID: 18341639 Free article.

9

Most acute myeloid leukaemia patients with intermediate mutant FLT3/ITD levels do not have detectable bi-allelic disease, indicating that heterozygous disease alone is associated with an adverse outcome.

Green C, Linch DC, Gale RE. Green C, et al. Among authors: linch dc. Br J Haematol. 2008 Jul;142(3):423-6. doi: 10.1111/j.1365-2141.2008.07196.x. Epub 2008 Jun 3. Br J Haematol. 2008. PMID: 18537976 Free article.

10

The production of JAK2 wild-type platelets is not downregulated in patients with JAK2 V617F mutant-positive essential thrombocythaemia.

Lambert JR, Gale RE, Linch DC. Lambert JR, et al. Among authors: linch dc. Br J Haematol. 2009 Apr;145(1):128-30. doi: 10.1111/j.1365-2141.2009.07597.x. Epub 2009 Jan 12. Br J Haematol. 2009. PMID: 19222478 Free article.

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