Shi H - Search Results

1

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.

Emert-Sedlak LA, Loughran HM, Shi H, Kulp JL 3rd, Shu ST, Zhao J, Day BW, Wrobel JE, Reitz AB, Smithgall TE. Emert-Sedlak LA, et al. Among authors: shi h. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1480-1484. doi: 10.1016/j.bmcl.2016.01.043. Epub 2016 Jan 21. Bioorg Med Chem Lett. 2016. PMID: 26852364 Free PMC article.

2

Structure of the HIV-1 full-length capsid protein in a conformationally trapped unassembled state induced by small-molecule binding.

Du S, Betts L, Yang R, Shi H, Concel J, Ahn J, Aiken C, Zhang P, Yeh JI. Du S, et al. Among authors: shi h. J Mol Biol. 2011 Feb 25;406(3):371-86. doi: 10.1016/j.jmb.2010.11.027. Epub 2010 Dec 10. J Mol Biol. 2011. PMID: 21146540 Free PMC article.

3

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. Pene-Dumitrescu T, et al. Among authors: shi h. BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1. BMC Chem Biol. 2012. PMID: 22420777 Free PMC article.

4

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.

Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE. Emert-Sedlak LA, et al. Among authors: shi h. Chem Biol. 2013 Jan 24;20(1):82-91. doi: 10.1016/j.chembiol.2012.11.005. Chem Biol. 2013. PMID: 23352142 Free PMC article.

5

Fluorescence Polarization Screening Assays for Small Molecule Allosteric Modulators of ABL Kinase Function.

Grover P, Shi H, Baumgartner M, Camacho CJ, Smithgall TE. Grover P, et al. Among authors: shi h. PLoS One. 2015 Jul 29;10(7):e0133590. doi: 10.1371/journal.pone.0133590. eCollection 2015. PLoS One. 2015. PMID: 26222440 Free PMC article.

6

c-Abl Tyrosine Kinase Adopts Multiple Active Conformational States in Solution.

Badger J, Grover P, Shi H, Panjarian SB, Engen JR, Smithgall TE, Makowski L. Badger J, et al. Among authors: shi h. Biochemistry. 2016 Jun 14;55(23):3251-60. doi: 10.1021/acs.biochem.6b00202. Epub 2016 Jun 3. Biochemistry. 2016. PMID: 27166638 Free PMC article.

7

Remodeling of HIV-1 Nef Structure by Src-Family Kinase Binding.

Moroco JA, Alvarado JJ, Staudt RP, Shi H, Wales TE, Smithgall TE, Engen JR. Moroco JA, et al. Among authors: shi h. J Mol Biol. 2018 Feb 2;430(3):310-321. doi: 10.1016/j.jmb.2017.12.008. Epub 2017 Dec 16. J Mol Biol. 2018. PMID: 29258818 Free PMC article.

8

The Src family kinase Fgr is a transforming oncoprotein that functions independently of SH3-SH2 domain regulation.

Shen K, Moroco JA, Patel RK, Shi H, Engen JR, Dorman HR, Smithgall TE. Shen K, et al. Among authors: shi h. Sci Signal. 2018 Oct 23;11(553):eaat5916. doi: 10.1126/scisignal.aat5916. Sci Signal. 2018. PMID: 30352950

9

Tight-Binding Hydroxypyrazole HIV-1 Nef Inhibitors Suppress Viral Replication in Donor Mononuclear Cells and Reverse Nef-Mediated MHC-I Downregulation.

Shi H, Tice CM, Emert-Sedlak L, Chen L, Li WF, Carlsen M, Wrobel JE, Reitz AB, Smithgall TE. Shi H, et al. ACS Infect Dis. 2020 Feb 14;6(2):302-312. doi: 10.1021/acsinfecdis.9b00382. Epub 2019 Dec 16. ACS Infect Dis. 2020. PMID: 31775511 Free PMC article.

10

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes.

Staudt RP, Alvarado JJ, Emert-Sedlak LA, Shi H, Shu ST, Wales TE, Engen JR, Smithgall TE. Staudt RP, et al. Among authors: shi h. J Biol Chem. 2020 Oct 30;295(44):15158-15171. doi: 10.1074/jbc.REV120.012317. Epub 2020 Aug 29. J Biol Chem. 2020. PMID: 32862141 Free PMC article. Review.

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