Shu ST - Search Results

1

Synthesis and evaluation of orally active small molecule HIV-1 Nef antagonists.

Emert-Sedlak LA, Loughran HM, Shi H, Kulp JL 3rd, Shu ST, Zhao J, Day BW, Wrobel JE, Reitz AB, Smithgall TE. Emert-Sedlak LA, et al. Among authors: shu st. Bioorg Med Chem Lett. 2016 Mar 1;26(5):1480-1484. doi: 10.1016/j.bmcl.2016.01.043. Epub 2016 Jan 21. Bioorg Med Chem Lett. 2016. PMID: 26852364 Free PMC article.

2

HIV-1 Nef interaction influences the ATP-binding site of the Src-family kinase, Hck.

Pene-Dumitrescu T, Shu ST, Wales TE, Alvarado JJ, Shi H, Narute P, Moroco JA, Yeh JI, Engen JR, Smithgall TE. Pene-Dumitrescu T, et al. Among authors: shu st. BMC Chem Biol. 2012 Mar 15;12:1. doi: 10.1186/1472-6769-12-1. BMC Chem Biol. 2012. PMID: 22420777 Free PMC article.

3

Effector kinase coupling enables high-throughput screens for direct HIV-1 Nef antagonists with antiretroviral activity.

Emert-Sedlak LA, Narute P, Shu ST, Poe JA, Shi H, Yanamala N, Alvarado JJ, Lazo JS, Yeh JI, Johnston PA, Smithgall TE. Emert-Sedlak LA, et al. Among authors: shu st. Chem Biol. 2013 Jan 24;20(1):82-91. doi: 10.1016/j.chembiol.2012.11.005. Chem Biol. 2013. PMID: 23352142 Free PMC article.

4

Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation.

Shu ST, Emert-Sedlak LA, Smithgall TE. Shu ST, et al. J Biol Chem. 2017 Feb 17;292(7):2670-2678. doi: 10.1074/jbc.M116.770016. Epub 2016 Dec 28. J Biol Chem. 2017. PMID: 28031466 Free PMC article.

5

Selective Inhibition of the Myeloid Src-Family Kinase Fgr Potently Suppresses AML Cell Growth in Vitro and in Vivo.

Weir MC, Shu ST, Patel RK, Hellwig S, Chen L, Tan L, Gray NS, Smithgall TE. Weir MC, et al. Among authors: shu st. ACS Chem Biol. 2018 Jun 15;13(6):1551-1559. doi: 10.1021/acschembio.8b00154. Epub 2018 May 30. ACS Chem Biol. 2018. PMID: 29763550 Free PMC article.

6

HIV-1 Nef dimers short-circuit immune receptor signaling by activating Tec-family kinases at the host cell membrane.

Li WF, Aryal M, Shu ST, Smithgall TE. Li WF, et al. Among authors: shu st. J Biol Chem. 2020 Apr 10;295(15):5163-5174. doi: 10.1074/jbc.RA120.012536. Epub 2020 Mar 6. J Biol Chem. 2020. PMID: 32144207 Free PMC article.

7

Structure, function, and inhibitor targeting of HIV-1 Nef-effector kinase complexes.

Staudt RP, Alvarado JJ, Emert-Sedlak LA, Shi H, Shu ST, Wales TE, Engen JR, Smithgall TE. Staudt RP, et al. Among authors: shu st. J Biol Chem. 2020 Oct 30;295(44):15158-15171. doi: 10.1074/jbc.REV120.012317. Epub 2020 Aug 29. J Biol Chem. 2020. PMID: 32862141 Free PMC article. Review.

8

Visualization of Host Cell Kinase Activation by Viral Proteins Using GFP Fluorescence Complementation and Immunofluorescence Microscopy.

Shu ST, Li WF, Smithgall TE. Shu ST, et al. Bio Protoc. 2021 Jul 5;11(13):e4068. doi: 10.21769/BioProtoc.4068. eCollection 2021 Jul 5. Bio Protoc. 2021. PMID: 34327265 Free PMC article.

9

Antiretroviral Drug Discovery Targeting the HIV-1 Nef Virulence Factor.

Emert-Sedlak LA, Shi H, Tice CM, Chen L, Alvarado JJ, Shu ST, Du S, Thomas CE, Wrobel JE, Reitz AB, Smithgall TE. Emert-Sedlak LA, et al. Among authors: shu st. Viruses. 2022 Sep 13;14(9):2025. doi: 10.3390/v14092025. Viruses. 2022. PMID: 36146831 Free PMC article. Review.

10

PROTAC-mediated Degradation of HIV-1 Nef Efficiently Restores Cell-surface CD4 and MHC-I Expression and Blocks HIV-1 Replication.

Emert-Sedlak LA, Tice CM, Shi H, Alvarado JJ, Shu ST, Reitz AB, Smithgall TE. Emert-Sedlak LA, et al. Among authors: shu st. bioRxiv [Preprint]. 2023 Sep 5:2023.08.14.553289. doi: 10.1101/2023.08.14.553289. bioRxiv. 2023. Update in: Cell Chem Biol. 2024 Apr 18;31(4):658-668.e14. doi: 10.1016/j.chembiol.2024.02.004 PMID: 37645900 Free PMC article. Updated. Preprint.

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