Georgescu R - Search Results

1

Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.

Yuan Z, Bai L, Sun J, Georgescu R, Liu J, O'Donnell ME, Li H. Yuan Z, et al. Among authors: georgescu r. Nat Struct Mol Biol. 2016 Mar;23(3):217-24. doi: 10.1038/nsmb.3170. Epub 2016 Feb 8. Nat Struct Mol Biol. 2016. PMID: 26854665 Free PMC article.

2

Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression.

Yao NY, Georgescu RE, Finkelstein J, O'Donnell ME. Yao NY, et al. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13236-41. doi: 10.1073/pnas.0906157106. Epub 2009 Aug 3. Proc Natl Acad Sci U S A. 2009. PMID: 19666586 Free PMC article.

3

Single-molecule studies reveal the function of a third polymerase in the replisome.

Georgescu RE, Kurth I, O'Donnell ME. Georgescu RE, et al. Nat Struct Mol Biol. 2011 Dec 11;19(1):113-6. doi: 10.1038/nsmb.2179. Nat Struct Mol Biol. 2011. PMID: 22157955 Free PMC article.

4

A solution to release twisted DNA during chromosome replication by coupled DNA polymerases.

Kurth I, Georgescu RE, O'Donnell ME. Kurth I, et al. Nature. 2013 Apr 4;496(7443):119-22. doi: 10.1038/nature11988. Epub 2013 Mar 27. Nature. 2013. PMID: 23535600 Free PMC article.

5

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.

Georgescu RE, Langston L, Yao NY, Yurieva O, Zhang D, Finkelstein J, Agarwal T, O'Donnell ME. Georgescu RE, et al. Nat Struct Mol Biol. 2014 Aug;21(8):664-70. doi: 10.1038/nsmb.2851. Epub 2014 Jul 6. Nat Struct Mol Biol. 2014. PMID: 24997598 Free PMC article.

6

CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.

Langston LD, Zhang D, Yurieva O, Georgescu RE, Finkelstein J, Yao NY, Indiani C, O'Donnell ME. Langston LD, et al. Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15390-5. doi: 10.1073/pnas.1418334111. Epub 2014 Oct 13. Proc Natl Acad Sci U S A. 2014. PMID: 25313033 Free PMC article.

7

The architecture of a eukaryotic replisome.

Sun J, Shi Y, Georgescu RE, Yuan Z, Chait BT, Li H, O'Donnell ME. Sun J, et al. Nat Struct Mol Biol. 2015 Dec;22(12):976-82. doi: 10.1038/nsmb.3113. Epub 2015 Nov 2. Nat Struct Mol Biol. 2015. PMID: 26524492 Free PMC article.

8

Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.

Georgescu R, Yuan Z, Bai L, de Luna Almeida Santos R, Sun J, Zhang D, Yurieva O, Li H, O'Donnell ME. Georgescu R, et al. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E697-E706. doi: 10.1073/pnas.1620500114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096349 Free PMC article.

9

Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks.

Langston LD, Mayle R, Schauer GD, Yurieva O, Zhang D, Yao NY, Georgescu RE, O'Donnell ME. Langston LD, et al. Among authors: georgescu re. Elife. 2017 Sep 4;6:e29118. doi: 10.7554/eLife.29118. Elife. 2017. PMID: 28869037 Free PMC article.

10

Architecture of the Saccharomyces cerevisiae Replisome.

Bai L, Yuan Z, Sun J, Georgescu R, O'Donnell ME, Li H. Bai L, et al. Among authors: georgescu r. Adv Exp Med Biol. 2017;1042:207-228. doi: 10.1007/978-981-10-6955-0_10. Adv Exp Med Biol. 2017. PMID: 29357060 Free PMC article. Review.

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