Podust LM - Search Results

1

X-ray structures of thioredoxin and thioredoxin reductase from Entamoeba histolytica and prevailing hypothesis of the mechanism of Auranofin action.

Parsonage D, Sheng F, Hirata K, Debnath A, McKerrow JH, Reed SL, Abagyan R, Poole LB, Podust LM. Parsonage D, et al. Among authors: podust lm. J Struct Biol. 2016 May;194(2):180-90. doi: 10.1016/j.jsb.2016.02.015. Epub 2016 Feb 12. J Struct Biol. 2016. PMID: 26876147 Free PMC article.

2

Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.

Chen CK, Doyle PS, Yermalitskaya LV, Mackey ZB, Ang KK, McKerrow JH, Podust LM. Chen CK, et al. Among authors: podust lm. PLoS Negl Trop Dis. 2009;3(2):e372. doi: 10.1371/journal.pntd.0000372. Epub 2009 Feb 3. PLoS Negl Trop Dis. 2009. PMID: 19190730 Free PMC article.

3

Two approaches to discovering and developing new drugs for Chagas disease.

McKerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. McKerrow JH, et al. Among authors: podust lm. Mem Inst Oswaldo Cruz. 2009 Jul;104 Suppl 1(0 1):263-9. doi: 10.1590/s0074-02762009000900034. Mem Inst Oswaldo Cruz. 2009. PMID: 19753483 Free PMC article.

4

A nonazole CYP51 inhibitor cures Chagas' disease in a mouse model of acute infection.

Doyle PS, Chen CK, Johnston JB, Hopkins SD, Leung SS, Jacobson MP, Engel JC, McKerrow JH, Podust LM. Doyle PS, et al. Among authors: podust lm. Antimicrob Agents Chemother. 2010 Jun;54(6):2480-8. doi: 10.1128/AAC.00281-10. Epub 2010 Apr 12. Antimicrob Agents Chemother. 2010. PMID: 20385875 Free PMC article.

5

Structural characterization of CYP51 from Trypanosoma cruzi and Trypanosoma brucei bound to the antifungal drugs posaconazole and fluconazole.

Chen CK, Leung SS, Guilbert C, Jacobson MP, McKerrow JH, Podust LM. Chen CK, et al. Among authors: podust lm. PLoS Negl Trop Dis. 2010 Apr 6;4(4):e651. doi: 10.1371/journal.pntd.0000651. PLoS Negl Trop Dis. 2010. PMID: 20386598 Free PMC article.

6

Diverse inhibitor chemotypes targeting Trypanosoma cruzi CYP51.

Gunatilleke SS, Calvet CM, Johnston JB, Chen CK, Erenburg G, Gut J, Engel JC, Ang KK, Mulvaney J, Chen S, Arkin MR, McKerrow JH, Podust LM. Gunatilleke SS, et al. Among authors: podust lm. PLoS Negl Trop Dis. 2012;6(7):e1736. doi: 10.1371/journal.pntd.0001736. Epub 2012 Jul 31. PLoS Negl Trop Dis. 2012. PMID: 22860142 Free PMC article.

7

Rational development of 4-aminopyridyl-based inhibitors targeting Trypanosoma cruzi CYP51 as anti-chagas agents.

Choi JY, Calvet CM, Gunatilleke SS, Ruiz C, Cameron MD, McKerrow JH, Podust LM, Roush WR. Choi JY, et al. Among authors: podust lm. J Med Chem. 2013 Oct 10;56(19):7651-68. doi: 10.1021/jm401067s. Epub 2013 Sep 30. J Med Chem. 2013. PMID: 24079662 Free PMC article.

8

R-Configuration of 4-Aminopyridyl-Based Inhibitors of CYP51 Confers Superior Efficacy Against Trypanosoma cruzi.

Choi JY, Calvet CM, Vieira DF, Gunatilleke SS, Cameron MD, McKerrow JH, Podust LM, Roush WR. Choi JY, et al. Among authors: podust lm. ACS Med Chem Lett. 2014 Jan 22;5(4):434-9. doi: 10.1021/ml500010m. eCollection 2014 Apr 10. ACS Med Chem Lett. 2014. PMID: 24900854 Free PMC article.

9

4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.

Calvet CM, Vieira DF, Choi JY, Kellar D, Cameron MD, Siqueira-Neto JL, Gut J, Johnston JB, Lin L, Khan S, McKerrow JH, Roush WR, Podust LM. Calvet CM, et al. Among authors: podust lm. J Med Chem. 2014 Aug 28;57(16):6989-7005. doi: 10.1021/jm500448u. Epub 2014 Aug 19. J Med Chem. 2014. PMID: 25101801 Free PMC article.

10

Binding mode and potency of N-indolyloxopyridinyl-4-aminopropanyl-based inhibitors targeting Trypanosoma cruzi CYP51.

Vieira DF, Choi JY, Calvet CM, Siqueira-Neto JL, Johnston JB, Kellar D, Gut J, Cameron MD, McKerrow JH, Roush WR, Podust LM. Vieira DF, et al. Among authors: podust lm. J Med Chem. 2014 Dec 11;57(23):10162-75. doi: 10.1021/jm501568b. Epub 2014 Nov 25. J Med Chem. 2014. PMID: 25393646 Free PMC article.

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