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Targeting of mitochondrial reactive oxygen species production does not avert lipid-induced insulin resistance in muscle tissue from mice.
Paglialunga S, van Bree B, Bosma M, Valdecantos MP, Amengual-Cladera E, Jörgensen JA, van Beurden D, den Hartog GJM, Ouwens DM, Briedé JJ, Schrauwen P, Hoeks J. Paglialunga S, et al. Among authors: bosma m. Diabetologia. 2012 Oct;55(10):2759-2768. doi: 10.1007/s00125-012-2626-x. Epub 2012 Jul 12. Diabetologia. 2012. PMID: 22782287
One-leg inactivity induces a reduction in mitochondrial oxidative capacity, intramyocellular lipid accumulation and reduced insulin signalling upon lipid infusion: a human study with unilateral limb suspension.
Bilet L, Phielix E, van de Weijer T, Gemmink A, Bosma M, Moonen-Kornips E, Jorgensen JA, Schaart G, Zhang D, Meijer K, Hopman M, Hesselink MKC, Ouwens DM, Shulman GI, Schrauwen-Hinderling VB, Schrauwen P. Bilet L, et al. Among authors: bosma m. Diabetologia. 2020 Jun;63(6):1211-1222. doi: 10.1007/s00125-020-05128-1. Epub 2020 Mar 17. Diabetologia. 2020. PMID: 32185462 Free PMC article.
The lipid droplet coat protein perilipin 5 also localizes to muscle mitochondria.
Bosma M, Minnaard R, Sparks LM, Schaart G, Losen M, de Baets MH, Duimel H, Kersten S, Bickel PE, Schrauwen P, Hesselink MK. Bosma M, et al. Histochem Cell Biol. 2012 Feb;137(2):205-16. doi: 10.1007/s00418-011-0888-x. Epub 2011 Nov 30. Histochem Cell Biol. 2012. PMID: 22127648 Free PMC article.
Augmenting muscle diacylglycerol and triacylglycerol content by blocking fatty acid oxidation does not impede insulin sensitivity.
Timmers S, Nabben M, Bosma M, van Bree B, Lenaers E, van Beurden D, Schaart G, Westerterp-Plantenga MS, Langhans W, Hesselink MK, Schrauwen-Hinderling VB, Schrauwen P. Timmers S, et al. Among authors: bosma m. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11711-6. doi: 10.1073/pnas.1206868109. Epub 2012 Jul 2. Proc Natl Acad Sci U S A. 2012. PMID: 22753483 Free PMC article.
235 results