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Page 1
Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.
Zheng Y, Zhuang L, Fan KY, Tice CM, Zhao W, Dong C, Lotesta SD, Leftheris K, Lindblom PR, Liu Z, Shimada J, Noto PB, Meng S, Hardy A, Howard L, Krosky P, Guo J, Lipinski K, Kandpal G, Bukhtiyarov Y, Zhao Y, Lala D, Van Orden R, Zhou J, Chen G, Wu Z, McKeever BM, McGeehan GM, Gregg RE, Claremon DA, Singh SB. Zheng Y, et al. Among authors: lotesta sd. J Med Chem. 2016 Apr 14;59(7):3264-71. doi: 10.1021/acs.jmedchem.5b02029. Epub 2016 Mar 29. J Med Chem. 2016. PMID: 26990539
Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.
Tice CM, Noto PB, Fan KY, Zhao W, Lotesta SD, Dong C, Marcus AP, Zheng YJ, Chen G, Wu Z, Van Orden R, Zhou J, Bukhtiyarov Y, Zhao Y, Lipinski K, Howard L, Guo J, Kandpal G, Meng S, Hardy A, Krosky P, Gregg RE, Leftheris K, McKeever BM, Singh SB, Lala D, McGeehan GM, Zhuang L, Claremon DA. Tice CM, et al. Among authors: lotesta sd. Bioorg Med Chem Lett. 2016 Oct 15;26(20):5044-5050. doi: 10.1016/j.bmcl.2016.08.089. Epub 2016 Aug 29. Bioorg Med Chem Lett. 2016. PMID: 27599745
Spirodiepoxide reaction with cuprates.
Ghosh P, Lotesta SD, Williams LJ. Ghosh P, et al. Among authors: lotesta sd. J Am Chem Soc. 2007 Mar 7;129(9):2438-9. doi: 10.1021/ja068813w. Epub 2007 Feb 9. J Am Chem Soc. 2007. PMID: 17288427 No abstract available.
Spirodiepoxides in total synthesis: epoxomicin.
Katukojvala S, Barlett KN, Lotesta SD, Williams LJ. Katukojvala S, et al. Among authors: lotesta sd. J Am Chem Soc. 2004 Dec 1;126(47):15348-9. doi: 10.1021/ja044563c. J Am Chem Soc. 2004. PMID: 15563139