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Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2.
Olayanju A, Copple IM, Bryan HK, Edge GT, Sison RL, Wong MW, Lai ZQ, Lin ZX, Dunn K, Sanderson CM, Alghanem AF, Cross MJ, Ellis EC, Ingelman-Sundberg M, Malik HZ, Kitteringham NR, Goldring CE, Park BK. Olayanju A, et al. Among authors: bryan hk. Free Radic Biol Med. 2015 Jan;78:202-12. doi: 10.1016/j.freeradbiomed.2014.11.003. Epub 2014 Nov 14. Free Radic Biol Med. 2015. PMID: 25445704 Free PMC article.