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60 YEARS OF POMC: Regulation of feeding and energy homeostasis by α-MSH.
Anderson EJ, Çakir I, Carrington SJ, Cone RD, Ghamari-Langroudi M, Gillyard T, Gimenez LE, Litt MJ. Anderson EJ, et al. Among authors: gimenez le. J Mol Endocrinol. 2016 May;56(4):T157-74. doi: 10.1530/JME-16-0014. Epub 2016 Mar 3. J Mol Endocrinol. 2016. PMID: 26939593 Free PMC article. Review.
The melanocortin-3 receptor is a pharmacological target for the regulation of anorexia.
Sweeney P, Bedenbaugh MN, Maldonado J, Pan P, Fowler K, Williams SY, Gimenez LE, Ghamari-Langroudi M, Downing G, Gui Y, Hadley CK, Joy ST, Mapp AK, Simerly RB, Cone RD. Sweeney P, et al. Among authors: gimenez le. Sci Transl Med. 2021 Apr 21;13(590):eabd6434. doi: 10.1126/scitranslmed.abd6434. Sci Transl Med. 2021. PMID: 33883274 Free PMC article.
Structure-Based Design of Melanocortin 4 Receptor Ligands Based on the SHU-9119-hMC4R Cocrystal Structure†.
Martin C, Gimenez LE, Williams SY, Jing Y, Wu Y, Hollanders C, Van der Poorten O, Gonzalez S, Van Holsbeeck K, Previti S, Lamouroux A, Zhao S, Tourwé D, Stevens RC, Cone RD, Ballet S. Martin C, et al. Among authors: gimenez le. J Med Chem. 2021 Jan 14;64(1):357-369. doi: 10.1021/acs.jmedchem.0c01620. Epub 2020 Nov 14. J Med Chem. 2021. PMID: 33190475
Demonstration of a Common DPhe7 to DNal(2')7 Peptide Ligand Antagonist Switch for Melanocortin-3 and Melanocortin-4 Receptors Identifies the Systematic Mischaracterization of the Pharmacological Properties of Melanocortin Peptides.
Gimenez LE, Noblin TA, Williams SY, Mullick Bagchi S, Ji RL, Tao YX, Jeppesen CB, Conde-Frieboes KW, Sawyer TK, Grieco P, Cone RD. Gimenez LE, et al. J Med Chem. 2022 Apr 28;65(8):5990-6000. doi: 10.1021/acs.jmedchem.1c01295. Epub 2022 Apr 11. J Med Chem. 2022. PMID: 35404053 Free PMC article.
36 results