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Page 1
(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.
Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R. Moutal A, et al. Among authors: xie jy. Pain. 2016 Jul;157(7):1448-1463. doi: 10.1097/j.pain.0000000000000555. Pain. 2016. PMID: 26967696 Free PMC article.
Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.
Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R. Moutal A, et al. Among authors: xie jy. Pain Rep. 2016 Jun;1(1):e565. doi: 10.1097/PR9.0000000000000565. Pain Rep. 2016. PMID: 27917413 Free PMC article.
CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.
Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R. Moutal A, et al. Among authors: xie jy. Pain. 2017 Dec;158(12):2301-2319. doi: 10.1097/j.pain.0000000000001002. Pain. 2017. PMID: 28809766 Free PMC article.
249 results