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Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage.
Hu SC, Bryant MS, Sepehr E, Kang HK, Trbojevich R, Lagaud G, Mehta D, Ding W, Mittelstaedt RA, Pearce MG, Bishop ME, Davis KJ, Lewis SM, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. Hu SC, et al. Among authors: chemerynski s. Toxicol Sci. 2021 Jul 16;182(1):10-28. doi: 10.1093/toxsci/kfab049. Toxicol Sci. 2021. PMID: 33944952
14-Day Nose-Only Inhalation Toxicity and Haber's Rule Study of NNK in Sprague-Dawley Rats.
Hu SC, Min S, Kang HK, Yang DJ, Lewis SM, Davis KJ, Patton RE, Bryant MS, Sepehr E, Trbojevich R, Pearce MG, Bishop ME, Heflich RH, Maisha MP, Felton R, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. Hu SC, et al. Among authors: chemerynski s. Toxicol Sci. 2021 Sep 28;183(2):319-337. doi: 10.1093/toxsci/kfab094. Toxicol Sci. 2021. PMID: 34329464
90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats.
Hu SC, Min S, Kang HK, Yang DJ, Basavarajappa M, Lewis SM, Davis KJ, Patton RE, Bryant MS, Sepehr E, Trbojevich R, Pearce MG, Bishop ME, Ding W, Heflich RH, Maisha MP, Felton R, Chemerynski S, Yee SB, Coraggio M, Rosenfeldt H, Yeager RP, Howard PC, Tang Y. Hu SC, et al. Among authors: chemerynski s. Food Chem Toxicol. 2022 Feb;160:112780. doi: 10.1016/j.fct.2021.112780. Epub 2021 Dec 26. Food Chem Toxicol. 2022. PMID: 34965465
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3'-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine.
Tang Y, Bryant MS, Li M, Min S, Pellar G, Wu Q, Yang DJ, Kang HK, Sepehr E, He X, McLellen F, Lewis SM, Greenhaw J, Fisher J, Yang X, Chemerynski S, Yee SB, Rosenfeldt H, Yeager RP, Howard PC, Hu SC, Roqué P, Goel R, Kc P, Yi J. Tang Y, et al. Among authors: chemerynski s. Toxicol Sci. 2024 Dec 1;202(2):196-209. doi: 10.1093/toxsci/kfae120. Toxicol Sci. 2024. PMID: 39270062
The fate of an inhaled cigarette puff in the human respiratory tract.
Asgharian B, Price O, Wasdo S, Li C, Peters KO, Haskins RM, Chemerynski S, Schroeter J. Asgharian B, et al. Among authors: chemerynski s. Inhal Toxicol. 2024 Jul;36(6):378-390. doi: 10.1080/08958378.2024.2367419. Epub 2024 Jun 23. Inhal Toxicol. 2024. PMID: 38909354
Use of a physiologically-based pharmacokinetic model to explore the potential disparity in nicotine disposition between adult and adolescent nonhuman primates.
Yang X, Naylor J, Matazel K, Goodwin A, Jacob CC, Bryant M, Loukotková L, Gamboa da Costa G, Chemerynski S, Deng-Bryant Y, Reissig C, Jackson K, Fisher J. Yang X, et al. Among authors: chemerynski s. Toxicol Appl Pharmacol. 2020 Jan 1;386:114826. doi: 10.1016/j.taap.2019.114826. Epub 2019 Nov 12. Toxicol Appl Pharmacol. 2020. PMID: 31730783
17 results