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Iminosugars Inhibit Dengue Virus Production via Inhibition of ER Alpha-Glucosidases--Not Glycolipid Processing Enzymes.
Sayce AC, Alonzi DS, Killingbeck SS, Tyrrell BE, Hill ML, Caputo AT, Iwaki R, Kinami K, Ide D, Kiappes JL, Beatty PR, Kato A, Harris E, Dwek RA, Miller JL, Zitzmann N. Sayce AC, et al. Among authors: kinami k. PLoS Negl Trop Dis. 2016 Mar 14;10(3):e0004524. doi: 10.1371/journal.pntd.0004524. eCollection 2016 Mar. PLoS Negl Trop Dis. 2016. PMID: 26974655 Free PMC article.
Inhibition of endoplasmic reticulum glucosidases is required for in vitro and in vivo dengue antiviral activity by the iminosugar UV-4.
Warfield KL, Plummer EM, Sayce AC, Alonzi DS, Tang W, Tyrrell BE, Hill ML, Caputo AT, Killingbeck SS, Beatty PR, Harris E, Iwaki R, Kinami K, Ide D, Kiappes JL, Kato A, Buck MD, King K, Eddy W, Khaliq M, Sampath A, Treston AM, Dwek RA, Enterlein SG, Miller JL, Zitzmann N, Ramstedt U, Shresta S. Warfield KL, et al. Among authors: kinami k. Antiviral Res. 2016 May;129:93-98. doi: 10.1016/j.antiviral.2016.03.001. Epub 2016 Mar 3. Antiviral Res. 2016. PMID: 26946111 Free PMC article.
Design and Synthesis of Labystegines, Hybrid Iminosugars from LAB and Calystegine, as Inhibitors of Intestinal α-Glucosidases: Binding Conformation and Interaction for ntSI.
Kato A, Zhang ZL, Wang HY, Jia YM, Yu CY, Kinami K, Hirokami Y, Tsuji Y, Adachi I, Nash RJ, Fleet GW, Koseki J, Nakagome I, Hirono S. Kato A, et al. Among authors: kinami k. J Org Chem. 2015 May 1;80(9):4501-15. doi: 10.1021/acs.joc.5b00342. Epub 2015 Apr 13. J Org Chem. 2015. PMID: 25843107
14 results