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A novel serine protease inhibitor as potential treatment for dry eye syndrome and ocular inflammation.
Joossen C, Baán A, Moreno-Cinos C, Joossens J, Cools N, Lanckacker E, Moons L, Lemmens K, Lambeir AM, Fransen E, Delputte P, Caljon G, Van Der Veken P, Maes L, De Meester I, Kiekens F, Augustyns K, Cos P. Joossen C, et al. Among authors: joossens j. Sci Rep. 2020 Oct 14;10(1):17268. doi: 10.1038/s41598-020-74159-w. Sci Rep. 2020. PMID: 33057006 Free PMC article.
Newly developed serine protease inhibitors decrease visceral hypersensitivity in a post-inflammatory rat model for irritable bowel syndrome.
Ceuleers H, Hanning N, Heirbaut J, Van Remoortel S, Joossens J, Van Der Veken P, Francque SM, De Bruyn M, Lambeir AM, De Man JG, Timmermans JP, Augustyns K, De Meester I, De Winter BY. Ceuleers H, et al. Among authors: joossens j. Br J Pharmacol. 2018 Sep;175(17):3516-3533. doi: 10.1111/bph.14396. Epub 2018 Jul 23. Br J Pharmacol. 2018. PMID: 29911328 Free PMC article.
P2-substituted N-acylprolylpyrrolidine inhibitors of prolyl oligopeptidase: biochemical evaluation, binding mode determination, and assessment in a cellular model of synucleinopathy.
Van der Veken P, Fülöp V, Rea D, Gerard M, Van Elzen R, Joossens J, Cheng JD, Baekelandt V, De Meester I, Lambeir AM, Augustyns K. Van der Veken P, et al. Among authors: joossens j. J Med Chem. 2012 Nov 26;55(22):9856-67. doi: 10.1021/jm301060g. Epub 2012 Nov 13. J Med Chem. 2012. PMID: 23121075
The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model.
Van Spaendonk H, Ceuleers H, Smet A, Berg M, Joossens J, Van der Veken P, Francque SM, Lambeir AM, De Man JG, De Meester I, Augustyns K, De Winter BY. Van Spaendonk H, et al. Among authors: joossens j. Front Pharmacol. 2021 Jun 24;12:682065. doi: 10.3389/fphar.2021.682065. eCollection 2021. Front Pharmacol. 2021. PMID: 34248633 Free PMC article.
198 results