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Identification of "Preferred" Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing?
Amata E, Xi H, Colmenarejo G, Gonzalez-Diaz R, Cordon-Obras C, Berlanga M, Manzano P, Erath J, Roncal NE, Lee PJ, Leed SE, Rodriguez A, Sciotti RJ, Navarro M, Pollastri MP. Amata E, et al. Among authors: navarro m. ACS Infect Dis. 2016 Mar 11;2(3):180-186. doi: 10.1021/acsinfecdis.5b00136. Epub 2016 Jan 17. ACS Infect Dis. 2016. PMID: 26998514 Free PMC article.
The susceptibility of trypanosomatid pathogens to PI3/mTOR kinase inhibitors affords a new opportunity for drug repurposing.
Diaz-Gonzalez R, Kuhlmann FM, Galan-Rodriguez C, Madeira da Silva L, Saldivia M, Karver CE, Rodriguez A, Beverley SM, Navarro M, Pollastri MP. Diaz-Gonzalez R, et al. Among authors: navarro m. PLoS Negl Trop Dis. 2011 Aug;5(8):e1297. doi: 10.1371/journal.pntd.0001297. Epub 2011 Aug 23. PLoS Negl Trop Dis. 2011. PMID: 21886855 Free PMC article.
Establishment of a structure-activity relationship of 1H-imidazo[4,5-c]quinoline-based kinase inhibitor NVP-BEZ235 as a lead for African sleeping sickness.
Seixas JD, Luengo-Arratta SA, Diaz R, Saldivia M, Rojas-Barros DI, Manzano P, Gonzalez S, Berlanga M, Smith TK, Navarro M, Pollastri MP. Seixas JD, et al. Among authors: navarro m. J Med Chem. 2014 Jun 12;57(11):4834-48. doi: 10.1021/jm500361r. Epub 2014 May 21. J Med Chem. 2014. PMID: 24805946 Free PMC article.
High-throughput screening platform for natural product-based drug discovery against 3 neglected tropical diseases: human African trypanosomiasis, leishmaniasis, and Chagas disease.
Annang F, Pérez-Moreno G, García-Hernández R, Cordon-Obras C, Martín J, Tormo JR, Rodríguez L, de Pedro N, Gómez-Pérez V, Valente M, Reyes F, Genilloud O, Vicente F, Castanys S, Ruiz-Pérez LM, Navarro M, Gamarro F, González-Pacanowska D. Annang F, et al. Among authors: navarro m. J Biomol Screen. 2015 Jan;20(1):82-91. doi: 10.1177/1087057114555846. Epub 2014 Oct 20. J Biomol Screen. 2015. PMID: 25332350
Identification and characterization of hundreds of potent and selective inhibitors of Trypanosoma brucei growth from a kinase-targeted library screening campaign.
Diaz R, Luengo-Arratta SA, Seixas JD, Amata E, Devine W, Cordon-Obras C, Rojas-Barros DI, Jimenez E, Ortega F, Crouch S, Colmenarejo G, Fiandor JM, Martin JJ, Berlanga M, Gonzalez S, Manzano P, Navarro M, Pollastri MP. Diaz R, et al. Among authors: navarro m. PLoS Negl Trop Dis. 2014 Oct 23;8(10):e3253. doi: 10.1371/journal.pntd.0003253. eCollection 2014 Oct. PLoS Negl Trop Dis. 2014. PMID: 25340575 Free PMC article.
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource.
Peña I, Pilar Manzano M, Cantizani J, Kessler A, Alonso-Padilla J, Bardera AI, Alvarez E, Colmenarejo G, Cotillo I, Roquero I, de Dios-Anton F, Barroso V, Rodriguez A, Gray DW, Navarro M, Kumar V, Sherstnev A, Drewry DH, Brown JR, Fiandor JM, Julio Martin J. Peña I, et al. Among authors: navarro m. Sci Rep. 2015 Mar 5;5:8771. doi: 10.1038/srep08771. Sci Rep. 2015. PMID: 25740547 Free PMC article.
Molecular evidence of a Trypanosoma brucei gambiense sylvatic cycle in the human african trypanosomiasis foci of Equatorial Guinea.
Cordon-Obras C, Rodriguez YF, Fernandez-Martinez A, Cano J, Ndong-Mabale N, Ncogo-Ada P, Ndongo-Asumu P, Aparicio P, Navarro M, Benito A, Bart JM. Cordon-Obras C, et al. Among authors: navarro m. Front Microbiol. 2015 Jul 24;6:765. doi: 10.3389/fmicb.2015.00765. eCollection 2015. Front Microbiol. 2015. PMID: 26257727 Free PMC article.
From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.
Devine WG, Diaz-Gonzalez R, Ceballos-Perez G, Rojas D, Satoh T, Tear W, Ranade RM, Barros-Álvarez X, Hol WG, Buckner FS, Navarro M, Pollastri MP. Devine WG, et al. Among authors: navarro m. ACS Infect Dis. 2017 Mar 10;3(3):225-236. doi: 10.1021/acsinfecdis.6b00202. Epub 2017 Feb 8. ACS Infect Dis. 2017. PMID: 28110521 Free PMC article.
2,679 results