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Suramin inhibits cullin-RING E3 ubiquitin ligases.
Wu K, Chong RA, Yu Q, Bai J, Spratt DE, Ching K, Lee C, Miao H, Tappin I, Hurwitz J, Zheng N, Shaw GS, Sun Y, Felsenfeld DP, Sanchez R, Zheng JN, Pan ZQ. Wu K, et al. Among authors: chong ra. Proc Natl Acad Sci U S A. 2016 Apr 5;113(14):E2011-8. doi: 10.1073/pnas.1601089113. Epub 2016 Mar 21. Proc Natl Acad Sci U S A. 2016. PMID: 27001857 Free PMC article.
Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination.
Chong RA, Wu K, Spratt DE, Yang Y, Lee C, Nayak J, Xu M, Elkholi R, Tappin I, Li J, Hurwitz J, Brown BD, Chipuk JE, Chen ZJ, Sanchez R, Shaw GS, Huang L, Pan ZQ. Chong RA, et al. Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8434-9. doi: 10.1073/pnas.1407849111. Epub 2014 May 27. Proc Natl Acad Sci U S A. 2014. PMID: 24912152 Free PMC article.
Brigatinib in NF2-Related Schwannomatosis with Progressive Tumors.
Plotkin SR, Yohay KH, Nghiemphu PL, Dinh CT, Babovic-Vuksanovic D, Merker VL, Bakker A, Fell G, Trippa L, Blakeley JO; INTUITT-NF2 Consortium. Plotkin SR, et al. N Engl J Med. 2024 Jun 27;390(24):2284-2294. doi: 10.1056/NEJMoa2400985. Epub 2024 Jun 21. N Engl J Med. 2024. PMID: 38904277 Clinical Trial.
32 results