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Candidalysin is a fungal peptide toxin critical for mucosal infection.
Moyes DL, Wilson D, Richardson JP, Mogavero S, Tang SX, Wernecke J, Höfs S, Gratacap RL, Robbins J, Runglall M, Murciano C, Blagojevic M, Thavaraj S, Förster TM, Hebecker B, Kasper L, Vizcay G, Iancu SI, Kichik N, Häder A, Kurzai O, Luo T, Krüger T, Kniemeyer O, Cota E, Bader O, Wheeler RT, Gutsmann T, Hube B, Naglik JR. Moyes DL, et al. Among authors: kasper l. Nature. 2016 Apr 7;532(7597):64-8. doi: 10.1038/nature17625. Epub 2016 Mar 30. Nature. 2016. PMID: 27027296 Free PMC article.
Secreted aspartic proteases of Candida albicans activate the NLRP3 inflammasome.
Pietrella D, Pandey N, Gabrielli E, Pericolini E, Perito S, Kasper L, Bistoni F, Cassone A, Hube B, Vecchiarelli A. Pietrella D, et al. Among authors: kasper l. Eur J Immunol. 2013 Mar;43(3):679-92. doi: 10.1002/eji.201242691. Epub 2013 Jan 31. Eur J Immunol. 2013. PMID: 23280543 Free article.
Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages.
Kasper L, Seider K, Gerwien F, Allert S, Brunke S, Schwarzmüller T, Ames L, Zubiria-Barrera C, Mansour MK, Becken U, Barz D, Vyas JM, Reiling N, Haas A, Haynes K, Kuchler K, Hube B. Kasper L, et al. PLoS One. 2014 May 1;9(5):e96015. doi: 10.1371/journal.pone.0096015. eCollection 2014. PLoS One. 2014. PMID: 24789333 Free PMC article.
One small step for a yeast--microevolution within macrophages renders Candida glabrata hypervirulent due to a single point mutation.
Brunke S, Seider K, Fischer D, Jacobsen ID, Kasper L, Jablonowski N, Wartenberg A, Bader O, Enache-Angoulvant A, Schaller M, d'Enfert C, Hube B. Brunke S, et al. Among authors: kasper l. PLoS Pathog. 2014 Oct 30;10(10):e1004478. doi: 10.1371/journal.ppat.1004478. eCollection 2014 Oct. PLoS Pathog. 2014. PMID: 25356907 Free PMC article.
346 results