Mutation of a single conserved nucleotide between the cloverleaf and internal ribosome entry site attenuates poliovirus neurovirulence.
De Jesus N, Franco D, Paul A, Wimmer E, Cello J.
De Jesus N, et al. Among authors: cello j.
J Virol. 2005 Nov;79(22):14235-43. doi: 10.1128/JVI.79.22.14235-14243.2005.
J Virol. 2005.
PMID: 16254358
Free PMC article.
The chemical synthesis of poliovirus (PV) cDNA combined with the cell-free synthesis of infectious particles yielded virus whose mouse neurovirulence was highly attenuated (J. Cello, A. V. Paul, and E. Wimmer, Science 297:1016-1018, 2002). Compared to the wild-type …
The chemical synthesis of poliovirus (PV) cDNA combined with the cell-free synthesis of infectious particles yielded virus whose mouse neuro …