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Snord116 is critical in the regulation of food intake and body weight.
Qi Y, Purtell L, Fu M, Lee NJ, Aepler J, Zhang L, Loh K, Enriquez RF, Baldock PA, Zolotukhin S, Campbell LV, Herzog H. Qi Y, et al. Among authors: loh k. Sci Rep. 2016 Jan 4;6:18614. doi: 10.1038/srep18614. Sci Rep. 2016. PMID: 26726071 Free PMC article.
Insulin controls food intake and energy balance via NPY neurons.
Loh K, Zhang L, Brandon A, Wang Q, Begg D, Qi Y, Fu M, Kulkarni R, Teo J, Baldock P, Brüning JC, Cooney G, Neely GG, Herzog H. Loh K, et al. Mol Metab. 2017 Apr 12;6(6):574-584. doi: 10.1016/j.molmet.2017.03.013. eCollection 2017 Jun. Mol Metab. 2017. PMID: 28580287 Free PMC article.
Inhibition of Y1 receptor signaling improves islet transplant outcome.
Loh K, Shi YC, Walters S, Bensellam M, Lee K, Dezaki K, Nakata M, Ip CK, Chan JY, Gurzov EN, Thomas HE, Waibel M, Cantley J, Kay TW, Yada T, Laybutt DR, Grey ST, Herzog H. Loh K, et al. Nat Commun. 2017 Sep 8;8(1):490. doi: 10.1038/s41467-017-00624-2. Nat Commun. 2017. PMID: 28887564 Free PMC article.
Neuropeptide Y1 receptor antagonism protects β-cells and improves glycemic control in type 2 diabetes.
Yang CH, Ann-Onda D, Lin X, Fynch S, Nadarajah S, Pappas EG, Liu X, Scott JW, Oakhill JS, Galic S, Shi Y, Moreno-Asso A, Smith C, Loudovaris T, Levinger I, Eizirik DL, Laybutt DR, Herzog H, Thomas HE, Loh K. Yang CH, et al. Among authors: loh k. Mol Metab. 2022 Jan;55:101413. doi: 10.1016/j.molmet.2021.101413. Epub 2021 Dec 7. Mol Metab. 2022. PMID: 34890851 Free PMC article.
Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.
Neopane K, Kozlov N, Negoita F, Murray-Segal L, Brink R, Hoque A, Ovens AJ, Tjin G, McAloon LM, Yu D, Ling NXY, Sanders MJ, Oakhill JS, Scott JW, Steinberg GR, Loh K, Kemp BE, Sakamoto K, Galic S. Neopane K, et al. Among authors: loh k. Cell Rep. 2022 Dec 20;41(12):111862. doi: 10.1016/j.celrep.2022.111862. Cell Rep. 2022. PMID: 36543129 Free article.
1,225 results