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Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.
Merlot AM, Shafie NH, Yu Y, Richardson V, Jansson PJ, Sahni S, Lane DJR, Kovacevic Z, Kalinowski DS, Richardson DR. Merlot AM, et al. Among authors: yu y. Biochem Pharmacol. 2016 Jun 1;109:27-47. doi: 10.1016/j.bcp.2016.04.001. Epub 2016 Apr 6. Biochem Pharmacol. 2016. PMID: 27059255
Iron chelators for the treatment of cancer.
Yu Y, Gutierrez E, Kovacevic Z, Saletta F, Obeidy P, Suryo Rahmanto Y, Richardson DR. Yu Y, et al. Curr Med Chem. 2012;19(17):2689-702. doi: 10.2174/092986712800609706. Curr Med Chem. 2012. PMID: 22455580 Review.
Design, synthesis, and characterization of novel iron chelators: structure-activity relationships of the 2-benzoylpyridine thiosemicarbazone series and their 3-nitrobenzoyl analogues as potent antitumor agents.
Kalinowski DS, Yu Y, Sharpe PC, Islam M, Liao YT, Lovejoy DB, Kumar N, Bernhardt PV, Richardson DR. Kalinowski DS, et al. Among authors: yu y. J Med Chem. 2007 Jul 26;50(15):3716-29. doi: 10.1021/jm070445z. Epub 2007 Jun 30. J Med Chem. 2007. PMID: 17602603
Tuning cell cycle regulation with an iron key.
Yu Y, Kovacevic Z, Richardson DR. Yu Y, et al. Cell Cycle. 2007 Aug 15;6(16):1982-94. doi: 10.4161/cc.6.16.4603. Epub 2007 Jun 19. Cell Cycle. 2007. PMID: 17721086 Review.
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