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Intracellular Na+ overload causes oxidation of CaMKII and leads to Ca2+ mishandling in isolated ventricular myocytes.
Viatchenko-Karpinski S, Kornyeyev D, El-Bizri N, Budas G, Fan P, Jiang Z, Yang J, Anderson ME, Shryock JC, Chang CP, Belardinelli L, Yao L. Viatchenko-Karpinski S, et al. Among authors: yao l. J Mol Cell Cardiol. 2014 Nov;76:247-56. doi: 10.1016/j.yjmcc.2014.09.009. Epub 2014 Sep 22. J Mol Cell Cardiol. 2014. PMID: 25252177 Free PMC article.
Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII.
Fischer TH, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, Sprenger JU, Fan P, Yao L, Popov AF, Danner BC, Schöndube F, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S. Fischer TH, et al. Among authors: yao l. Cardiovasc Res. 2015 Jul 1;107(1):184-96. doi: 10.1093/cvr/cvv153. Epub 2015 May 18. Cardiovasc Res. 2015. PMID: 25990311 Free PMC article.
Contribution of the late sodium current to intracellular sodium and calcium overload in rabbit ventricular myocytes treated by anemone toxin.
Kornyeyev D, El-Bizri N, Hirakawa R, Nguyen S, Viatchenko-Karpinski S, Yao L, Rajamani S, Belardinelli L. Kornyeyev D, et al. Among authors: yao l. Am J Physiol Heart Circ Physiol. 2016 Feb 1;310(3):H426-35. doi: 10.1152/ajpheart.00520.2015. Epub 2015 Dec 4. Am J Physiol Heart Circ Physiol. 2016. PMID: 26637557 Free article.
A novel, potent, and selective inhibitor of cardiac late sodium current suppresses experimental arrhythmias.
Belardinelli L, Liu G, Smith-Maxwell C, Wang WQ, El-Bizri N, Hirakawa R, Karpinski S, Li CH, Hu L, Li XJ, Crumb W, Wu L, Koltun D, Zablocki J, Yao L, Dhalla AK, Rajamani S, Shryock JC. Belardinelli L, et al. Among authors: yao l. J Pharmacol Exp Ther. 2013 Jan;344(1):23-32. doi: 10.1124/jpet.112.198887. Epub 2012 Sep 25. J Pharmacol Exp Ther. 2013. PMID: 23010360
Late sodium current inhibition reverses electromechanical dysfunction in human hypertrophic cardiomyopathy.
Coppini R, Ferrantini C, Yao L, Fan P, Del Lungo M, Stillitano F, Sartiani L, Tosi B, Suffredini S, Tesi C, Yacoub M, Olivotto I, Belardinelli L, Poggesi C, Cerbai E, Mugelli A. Coppini R, et al. Among authors: yao l. Circulation. 2013 Feb 5;127(5):575-84. doi: 10.1161/CIRCULATIONAHA.112.134932. Epub 2012 Dec 27. Circulation. 2013. PMID: 23271797
8,914 results