Gewirth DT - Search Results

1

Clients and Oncogenic Roles of Molecular Chaperone gp96/grp94.

Ansa-Addo EA, Thaxton J, Hong F, Wu BX, Zhang Y, Fugle CW, Metelli A, Riesenberg B, Williams K, Gewirth DT, Chiosis G, Liu B, Li Z. Ansa-Addo EA, et al. Among authors: gewirth dt. Curr Top Med Chem. 2016;16(25):2765-78. doi: 10.2174/1568026616666160413141613. Curr Top Med Chem. 2016. PMID: 27072698 Free PMC article. Review.

2

Identification of potent water soluble purine-scaffold inhibitors of the heat shock protein 90.

He H, Zatorska D, Kim J, Aguirre J, Llauger L, She Y, Wu N, Immormino RM, Gewirth DT, Chiosis G. He H, et al. Among authors: gewirth dt. J Med Chem. 2006 Jan 12;49(1):381-90. doi: 10.1021/jm0508078. J Med Chem. 2006. PMID: 16392823

3

Structural and quantum chemical studies of 8-aryl-sulfanyl adenine class Hsp90 inhibitors.

Immormino RM, Kang Y, Chiosis G, Gewirth DT. Immormino RM, et al. Among authors: gewirth dt. J Med Chem. 2006 Aug 10;49(16):4953-60. doi: 10.1021/jm060297x. J Med Chem. 2006. PMID: 16884307

4

The molecular chaperone gp96/GRP94 interacts with Toll-like receptors and integrins via its C-terminal hydrophobic domain.

Wu S, Hong F, Gewirth D, Guo B, Liu B, Li Z. Wu S, et al. J Biol Chem. 2012 Feb 24;287(9):6735-42. doi: 10.1074/jbc.M111.309526. Epub 2012 Jan 5. J Biol Chem. 2012. PMID: 22223641 Free PMC article.

5

α7 helix region of αI domain is crucial for integrin binding to endoplasmic reticulum chaperone gp96: a potential therapeutic target for cancer metastasis.

Hong F, Liu B, Chiosis G, Gewirth DT, Li Z. Hong F, et al. Among authors: gewirth dt. J Biol Chem. 2013 Jun 21;288(25):18243-8. doi: 10.1074/jbc.M113.468850. Epub 2013 May 13. J Biol Chem. 2013. PMID: 23671277 Free PMC article.

6

Experimental and structural testing module to analyze paralogue-specificity and affinity in the Hsp90 inhibitors series.

Taldone T, Patel PD, Patel M, Patel HJ, Evans CE, Rodina A, Ochiana S, Shah SK, Uddin M, Gewirth D, Chiosis G. Taldone T, et al. J Med Chem. 2013 Sep 12;56(17):6803-18. doi: 10.1021/jm400619b. Epub 2013 Aug 21. J Med Chem. 2013. PMID: 23965125 Free PMC article.

7

Characterization of the Grp94/OS-9 chaperone-lectin complex.

Seidler PM, Shinsky SA, Hong F, Li Z, Cosgrove MS, Gewirth DT. Seidler PM, et al. Among authors: gewirth dt. J Mol Biol. 2014 Oct 23;426(21):3590-605. doi: 10.1016/j.jmb.2014.08.024. Epub 2014 Sep 3. J Mol Biol. 2014. PMID: 25193139 Free PMC article.

8

Structure-activity relationship in a purine-scaffold compound series with selectivity for the endoplasmic reticulum Hsp90 paralog Grp94.

Patel HJ, Patel PD, Ochiana SO, Yan P, Sun W, Patel MR, Shah SK, Tramentozzi E, Brooks J, Bolaender A, Shrestha L, Stephani R, Finotti P, Leifer C, Li Z, Gewirth DT, Taldone T, Chiosis G. Patel HJ, et al. Among authors: gewirth dt. J Med Chem. 2015 May 14;58(9):3922-43. doi: 10.1021/acs.jmedchem.5b00197. Epub 2015 Apr 22. J Med Chem. 2015. PMID: 25901531 Free PMC article.

9

Exploring the Functional Complementation between Grp94 and Hsp90.

Maharaj KA, Que NL, Hong F, Huck JD, Gill SK, Wu S, Li Z, Gewirth DT. Maharaj KA, et al. Among authors: gewirth dt. PLoS One. 2016 Nov 8;11(11):e0166271. doi: 10.1371/journal.pone.0166271. eCollection 2016. PLoS One. 2016. PMID: 27824935 Free PMC article.

10

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Huck JD, Que NL, Hong F, Li Z, Gewirth DT. Huck JD, et al. Among authors: gewirth dt. Cell Rep. 2017 Sep 19;20(12):2800-2809. doi: 10.1016/j.celrep.2017.08.079. Cell Rep. 2017. PMID: 28930677 Free PMC article.

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