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Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells.
Guillem-Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V, Cirillo M, Patrono C, FitzGerald GA, Steinhilber D, Sgambato A, Patrignani P. Guillem-Llobat P, et al. Among authors: sacco a. Oncotarget. 2016 May 31;7(22):32462-77. doi: 10.18632/oncotarget.8655. Oncotarget. 2016. PMID: 27074574 Free PMC article.
Low-Dose Aspirin Acetylates Cyclooxygenase-1 in Human Colorectal Mucosa: Implications for the Chemoprevention of Colorectal Cancer.
Patrignani P, Sacco A, Sostres C, Bruno A, Dovizio M, Piazuelo E, Di Francesco L, Contursi A, Zucchelli M, Schiavone S, Tacconelli S, Patrono C, Lanas A. Patrignani P, et al. Among authors: sacco a. Clin Pharmacol Ther. 2017 Jul;102(1):52-61. doi: 10.1002/cpt.639. Epub 2017 Apr 4. Clin Pharmacol Ther. 2017. PMID: 28139830 Clinical Trial.
Platelet-Specific Deletion of Cyclooxygenase-1 Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice.
Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, Sgambato A, Patrono C, FitzGerald GA, Yu Y, Patrignani P. Sacco A, et al. J Pharmacol Exp Ther. 2019 Sep;370(3):416-426. doi: 10.1124/jpet.119.259382. Epub 2019 Jun 27. J Pharmacol Exp Ther. 2019. PMID: 31248980
Low-dose Aspirin prevents hypertension and cardiac fibrosis when thromboxane A2 is unrestrained.
D'Agostino I, Tacconelli S, Bruno A, Contursi A, Mucci L, Hu X, Xie Y, Chakraborty R, Jain K, Sacco A, Zucchelli M, Landolfi R, Dovizio M, Falcone L, Ballerini P, Hwa J, Patrignani P. D'Agostino I, et al. Among authors: sacco a. Pharmacol Res. 2021 Aug;170:105744. doi: 10.1016/j.phrs.2021.105744. Epub 2021 Jun 26. Pharmacol Res. 2021. PMID: 34182131 Free article.
682 results