Maurer CK - Search Results

1

Dissecting the Multiple Roles of PqsE in Pseudomonas aeruginosa Virulence by Discovery of Small Tool Compounds.

Zender M, Witzgall F, Drees SL, Weidel E, Maurer CK, Fetzner S, Blankenfeldt W, Empting M, Hartmann RW. Zender M, et al. Among authors: maurer ck. ACS Chem Biol. 2016 Jun 17;11(6):1755-63. doi: 10.1021/acschembio.6b00156. Epub 2016 Apr 28. ACS Chem Biol. 2016. PMID: 27082157

2

Discovery of antagonists of PqsR, a key player in 2-alkyl-4-quinolone-dependent quorum sensing in Pseudomonas aeruginosa.

Lu C, Kirsch B, Zimmer C, de Jong JC, Henn C, Maurer CK, Müsken M, Häussler S, Steinbach A, Hartmann RW. Lu C, et al. Among authors: maurer ck. Chem Biol. 2012 Mar 23;19(3):381-90. doi: 10.1016/j.chembiol.2012.01.015. Chem Biol. 2012. PMID: 22444593

3

Identification of small-molecule antagonists of the Pseudomonas aeruginosa transcriptional regulator PqsR: biophysically guided hit discovery and optimization.

Klein T, Henn C, de Jong JC, Zimmer C, Kirsch B, Maurer CK, Pistorius D, Müller R, Steinbach A, Hartmann RW. Klein T, et al. Among authors: maurer ck. ACS Chem Biol. 2012 Sep 21;7(9):1496-501. doi: 10.1021/cb300208g. Epub 2012 Jul 5. ACS Chem Biol. 2012. PMID: 22765028

4

Validation of PqsD as an anti-biofilm target in Pseudomonas aeruginosa by development of small-molecule inhibitors.

Storz MP, Maurer CK, Zimmer C, Wagner N, Brengel C, de Jong JC, Lucas S, Müsken M, Häussler S, Steinbach A, Hartmann RW. Storz MP, et al. Among authors: maurer ck. J Am Chem Soc. 2012 Oct 3;134(39):16143-6. doi: 10.1021/ja3072397. Epub 2012 Sep 24. J Am Chem Soc. 2012. PMID: 22992202

5

Discovery and biophysical characterization of 2-amino-oxadiazoles as novel antagonists of PqsR, an important regulator of Pseudomonas aeruginosa virulence.

Zender M, Klein T, Henn C, Kirsch B, Maurer CK, Kail D, Ritter C, Dolezal O, Steinbach A, Hartmann RW. Zender M, et al. Among authors: maurer ck. J Med Chem. 2013 Sep 12;56(17):6761-74. doi: 10.1021/jm400830r. Epub 2013 Aug 21. J Med Chem. 2013. PMID: 23919758

6

Flexible Fragment Growing Boosts Potency of Quorum-Sensing Inhibitors against Pseudomonas aeruginosa Virulence.

Zender M, Witzgall F, Kiefer A, Kirsch B, Maurer CK, Kany AM, Xu N, Schmelz S, Börger C, Blankenfeldt W, Empting M. Zender M, et al. Among authors: maurer ck. ChemMedChem. 2020 Jan 17;15(2):188-194. doi: 10.1002/cmdc.201900621. Epub 2019 Nov 28. ChemMedChem. 2020. PMID: 31709767 Free PMC article.

7

Development and validation of a UHPLC-MS/MS procedure for quantification of the Pseudomonas Quinolone Signal in bacterial culture after acetylation for characterization of new quorum sensing inhibitors.

Maurer CK, Steinbach A, Hartmann RW. Maurer CK, et al. J Pharm Biomed Anal. 2013 Dec;86:127-34. doi: 10.1016/j.jpba.2013.07.047. Epub 2013 Aug 14. J Pharm Biomed Anal. 2013. PMID: 24001903

8

Overcoming the unexpected functional inversion of a PqsR antagonist in Pseudomonas aeruginosa: an in vivo potent antivirulence agent targeting pqs quorum sensing.

Lu C, Maurer CK, Kirsch B, Steinbach A, Hartmann RW. Lu C, et al. Among authors: maurer ck. Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1109-12. doi: 10.1002/anie.201307547. Epub 2013 Dec 11. Angew Chem Int Ed Engl. 2014. PMID: 24338917

9

Optimization of anti-virulence PqsR antagonists regarding aqueous solubility and biological properties resulting in new insights in structure-activity relationships.

Lu C, Kirsch B, Maurer CK, de Jong JC, Braunshausen A, Steinbach A, Hartmann RW. Lu C, et al. Among authors: maurer ck. Eur J Med Chem. 2014 May 22;79:173-83. doi: 10.1016/j.ejmech.2014.04.016. Epub 2014 Apr 5. Eur J Med Chem. 2014. PMID: 24735643

10

Antibiotic-free nanotherapeutics: ultra-small, mucus-penetrating solid lipid nanoparticles enhance the pulmonary delivery and anti-virulence efficacy of novel quorum sensing inhibitors.

Nafee N, Husari A, Maurer CK, Lu C, de Rossi C, Steinbach A, Hartmann RW, Lehr CM, Schneider M. Nafee N, et al. Among authors: maurer ck. J Control Release. 2014 Oct 28;192:131-40. doi: 10.1016/j.jconrel.2014.06.055. Epub 2014 Jul 3. J Control Release. 2014. PMID: 24997276

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