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The live attenuated dengue vaccine TV003 elicits complete protection against dengue in a human challenge model.
Kirkpatrick BD, Whitehead SS, Pierce KK, Tibery CM, Grier PL, Hynes NA, Larsson CJ, Sabundayo BP, Talaat KR, Janiak A, Carmolli MP, Luke CJ, Diehl SA, Durbin AP. Kirkpatrick BD, et al. Among authors: whitehead ss. Sci Transl Med. 2016 Mar 16;8(330):330ra36. doi: 10.1126/scitranslmed.aaf1517. Epub 2016 Mar 16. Sci Transl Med. 2016. PMID: 27089205 Clinical Trial.
Introduction of mutations into the non-structural genes or 3' untranslated region of an attenuated dengue virus type 4 vaccine candidate further decreases replication in rhesus monkeys while retaining protective immunity.
Hanley KA, Manlucu LR, Manipon GG, Hanson CT, Whitehead SS, Murphy BR, Blaney JE Jr. Hanley KA, et al. Among authors: whitehead ss. Vaccine. 2004 Sep 3;22(25-26):3440-8. doi: 10.1016/j.vaccine.2004.02.031. Vaccine. 2004. PMID: 15308370
169 results