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Page 1
Preclinical Safety Profile of a Depleting Antibody against CRTh2 for Asthma: Well Tolerated Despite Unexpected CRTh2 Expression on Vascular Pericytes in the Central Nervous System and Gastric Mucosa.
Rajapaksa KS, Huang T, Sharma N, Liu S, Solon M, Reyes A, Paul S, Yee A, Tao J, Chalasani S, Bien-Ly N, Barck K, Carano RA, Wang J, Rangell L, Bremer M, Danilenko DM, Katavolos P, Hotzel I, Reif K, Austin CD. Rajapaksa KS, et al. Among authors: rangell l. Toxicol Sci. 2016 Jul;152(1):72-84. doi: 10.1093/toxsci/kfw067. Epub 2016 Apr 21. Toxicol Sci. 2016. PMID: 27103662
A novel inhibitor of the alternative pathway of complement reverses inflammation and bone destruction in experimental arthritis.
Katschke KJ Jr, Helmy KY, Steffek M, Xi H, Yin J, Lee WP, Gribling P, Barck KH, Carano RA, Taylor RE, Rangell L, Diehl L, Hass PE, Wiesmann C, van Lookeren Campagne M. Katschke KJ Jr, et al. Among authors: rangell l. J Exp Med. 2007 Jun 11;204(6):1319-25. doi: 10.1084/jem.20070432. Epub 2007 Jun 4. J Exp Med. 2007. PMID: 17548523 Free PMC article.
Genetic deletion of JAM-C reveals a role in myeloid progenitor generation.
Praetor A, McBride JM, Chiu H, Rangell L, Cabote L, Lee WP, Cupp J, Danilenko DM, Fong S. Praetor A, et al. Among authors: rangell l. Blood. 2009 Feb 26;113(9):1919-28. doi: 10.1182/blood-2008-06-159574. Epub 2008 Dec 24. Blood. 2009. PMID: 19109565 Free PMC article.
Global defects in collagen secretion in a Mia3/TANGO1 knockout mouse.
Wilson DG, Phamluong K, Li L, Sun M, Cao TC, Liu PS, Modrusan Z, Sandoval WN, Rangell L, Carano RA, Peterson AS, Solloway MJ. Wilson DG, et al. Among authors: rangell l. J Cell Biol. 2011 May 30;193(5):935-51. doi: 10.1083/jcb.201007162. Epub 2011 May 23. J Cell Biol. 2011. PMID: 21606205 Free PMC article.
Brain Distribution and Efficacy of the Brain Penetrant PI3K Inhibitor GDC-0084 in Orthotopic Mouse Models of Human Glioblastoma.
Salphati L, Alicke B, Heffron TP, Shahidi-Latham S, Nishimura M, Cao T, Carano RA, Cheong J, Greve J, Koeppen H, Lau S, Lee LB, Nannini-Pepe M, Pang J, Plise EG, Quiason C, Rangell L, Zhang X, Gould SE, Phillips HS, Olivero AG. Salphati L, et al. Among authors: rangell l. Drug Metab Dispos. 2016 Dec;44(12):1881-1889. doi: 10.1124/dmd.116.071423. Epub 2016 Sep 16. Drug Metab Dispos. 2016. PMID: 27638506
Mice expressing a humanized form of VEGF-A may provide insights into the safety and efficacy of anti-VEGF antibodies.
Gerber HP, Wu X, Yu L, Wiesmann C, Liang XH, Lee CV, Fuh G, Olsson C, Damico L, Xie D, Meng YG, Gutierrez J, Corpuz R, Li B, Hall L, Rangell L, Ferrando R, Lowman H, Peale F, Ferrara N. Gerber HP, et al. Among authors: rangell l. Proc Natl Acad Sci U S A. 2007 Feb 27;104(9):3478-83. doi: 10.1073/pnas.0611492104. Epub 2007 Feb 20. Proc Natl Acad Sci U S A. 2007. PMID: 17360669 Free PMC article.
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