Beutler JA - Search Results

1

Synthesis of a stable and orally bioavailable englerin analogue.

Fash DM, Peer CJ, Li Z, Talisman IJ, Hayavi S, Sulzmaier FJ, Ramos JW, Sourbier C, Neckers L, Figg WD, Beutler JA, Chain WJ. Fash DM, et al. Among authors: beutler ja. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2641-4. doi: 10.1016/j.bmcl.2016.04.016. Epub 2016 Apr 8. Bioorg Med Chem Lett. 2016. PMID: 27107948 Free PMC article.

2

Isolation and characterization of novel cytotoxic saponins from Archidendron ellipticum.

Beutler JA, Kashman Y, Pannell LK, Cardellina JH 2nd, Alexander MR, Balaschak MS, Prather TR, Shoemaker RH, Boyd MR. Beutler JA, et al. Bioorg Med Chem. 1997 Aug;5(8):1509-17. doi: 10.1016/s0968-0896(97)00098-9. Bioorg Med Chem. 1997. PMID: 9313857

3

Structure-activity requirements for flavone cytotoxicity and binding to tubulin.

Beutler JA, Hamel E, Vlietinck AJ, Haemers A, Rajan P, Roitman JN, Cardellina JH 2nd, Boyd MR. Beutler JA, et al. J Med Chem. 1998 Jun 18;41(13):2333-8. doi: 10.1021/jm970842h. J Med Chem. 1998. PMID: 9632366

4

Englerin A, a selective inhibitor of renal cancer cell growth, from Phyllanthus engleri.

Ratnayake R, Covell D, Ransom TT, Gustafson KR, Beutler JA. Ratnayake R, et al. Among authors: beutler ja. Org Lett. 2009 Jan 1;11(1):57-60. doi: 10.1021/ol802339w. Org Lett. 2009. PMID: 19061394 Free PMC article.

5

Structural analogues of schweinfurthin F: probing the steric, electronic, and hydrophobic properties of the D-ring substructure.

Ulrich NC, Kodet JG, Mente NR, Kuder CH, Beutler JA, Hohl RJ, Wiemer DF. Ulrich NC, et al. Among authors: beutler ja. Bioorg Med Chem. 2010 Feb 15;18(4):1676-83. doi: 10.1016/j.bmc.2009.12.063. Epub 2010 Jan 4. Bioorg Med Chem. 2010. PMID: 20116262 Free PMC article.

6

Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

Chung S, Himmel DM, Jiang JK, Wojtak K, Bauman JD, Rausch JW, Wilson JA, Beutler JA, Thomas CJ, Arnold E, Le Grice SF. Chung S, et al. Among authors: beutler ja. J Med Chem. 2011 Jul 14;54(13):4462-73. doi: 10.1021/jm2000757. Epub 2011 Jun 2. J Med Chem. 2011. PMID: 21568335 Free PMC article.

7

Relevance of the C-5 position to schweinfurthin induced cytotoxicity.

Topczewski JJ, Callahan MP, Kodet JG, Inbarasu JD, Mente NR, Beutler JA, Wiemer DF. Topczewski JJ, et al. Among authors: beutler ja. Bioorg Med Chem. 2011 Dec 15;19(24):7570-81. doi: 10.1016/j.bmc.2011.10.034. Epub 2011 Oct 19. Bioorg Med Chem. 2011. PMID: 22055715 Free PMC article.

8

Englerin A stimulates PKCθ to inhibit insulin signaling and to simultaneously activate HSF1: pharmacologically induced synthetic lethality.

Sourbier C, Scroggins BT, Ratnayake R, Prince TL, Lee S, Lee MJ, Nagy PL, Lee YH, Trepel JB, Beutler JA, Linehan WM, Neckers L. Sourbier C, et al. Among authors: beutler ja. Cancer Cell. 2013 Feb 11;23(2):228-37. doi: 10.1016/j.ccr.2012.12.007. Epub 2013 Jan 23. Cancer Cell. 2013. PMID: 23352416 Free PMC article.

9

Synthesis and structure activity relationships of schweinfurthin indoles.

Kodet JG, Beutler JA, Wiemer DF. Kodet JG, et al. Among authors: beutler ja. Bioorg Med Chem. 2014 Apr 15;22(8):2542-52. doi: 10.1016/j.bmc.2014.02.043. Epub 2014 Mar 6. Bioorg Med Chem. 2014. PMID: 24656801 Free PMC article.

10

Tonantzitlolone cytotoxicity toward renal cancer cells is PKCθ- and HSF1-dependent.

Sourbier C, Scroggins BT, Mannes PZ, Liao PJ, Siems K, Wolf D, Beutler JA, Linehan WM, Neckers L. Sourbier C, et al. Among authors: beutler ja. Oncotarget. 2015 Oct 6;6(30):29963-74. doi: 10.18632/oncotarget.4676. Oncotarget. 2015. PMID: 26298773 Free PMC article.

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