Li Q - Search Results

1

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway.

Pang T, Wang YJ, Gao YX, Xu Y, Li Q, Zhou YB, Xu L, Huang ZJ, Liao H, Zhang LY, Gao JR, Ye Q, Li J. Pang T, et al. Among authors: li j, li q. Acta Pharmacol Sin. 2016 Jun;37(6):741-52. doi: 10.1038/aps.2016.3. Epub 2016 Apr 25. Acta Pharmacol Sin. 2016. PMID: 27108601 Free PMC article.

2

Synthesis and biological evaluation of 3-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-4-(indol-3-yl)-maleimides as potent, selective GSK-3β inhibitors and neuroprotective agents.

Ye Q, Mao W, Zhou Y, Xu L, Li Q, Gao Y, Wang J, Li C, Xu Y, Xu Y, Liao H, Zhang L, Gao J, Li J, Pang T. Ye Q, et al. Among authors: li c, li j, li q. Bioorg Med Chem. 2015 Mar 1;23(5):1179-88. doi: 10.1016/j.bmc.2014.12.026. Epub 2014 Dec 20. Bioorg Med Chem. 2015. PMID: 25662701

3

Synthesis and Evaluation of 3-(furo[2,3-b]pyridin-3-yl)-4-(1H-indol-3-yl)-maleimides as Novel GSK-3β Inhibitors and Anti-Ischemic Agents.

Ye Q, Li Q, Zhou Y, Xu L, Mao W, Gao Y, Li C, Xu Y, Xu Y, Liao H, Zhang L, Gao J, Li J, Pang T. Ye Q, et al. Among authors: li c, li j, li q. Chem Biol Drug Des. 2015 Oct;86(4):746-52. doi: 10.1111/cbdd.12546. Epub 2015 Mar 16. Chem Biol Drug Des. 2015. PMID: 25711384

4

Y08197 is a novel and selective CBP/EP300 bromodomain inhibitor for the treatment of prostate cancer.

Zou LJ, Xiang QP, Xue XQ, Zhang C, Li CC, Wang C, Li Q, Wang R, Wu S, Zhou YL, Zhang Y, Xu Y. Zou LJ, et al. Among authors: li cc, li q. Acta Pharmacol Sin. 2019 Nov;40(11):1436-1447. doi: 10.1038/s41401-019-0237-5. Epub 2019 May 16. Acta Pharmacol Sin. 2019. PMID: 31097763 Free PMC article.

5

Development of pteridin-7(8H)-one analogues as highly potent cyclin-dependent kinase 4/6 inhibitors: Synthesis, structure-activity relationship, and biological activity.

Li Q, Chen L, Ma YF, Jian XE, Ji JH, You WW, Zhao PL. Li Q, et al. Bioorg Chem. 2021 Nov;116:105324. doi: 10.1016/j.bioorg.2021.105324. Epub 2021 Sep 2. Bioorg Chem. 2021. PMID: 34509794

6

Synthesis and biological evaluation of novel indole-pyrimidine hybrids bearing morpholine and thiomorpholine moieties.

Diao PC, Li Q, Hu MJ, Ma YF, You WW, Hong KH, Zhao PL. Diao PC, et al. Among authors: li q. Eur J Med Chem. 2017 Jul 7;134:110-118. doi: 10.1016/j.ejmech.2017.04.011. Epub 2017 Apr 7. Eur J Med Chem. 2017. PMID: 28410492

7

Discovery and Characterization of Benzimidazole Derivative XY123 as a Potent, Selective, and Orally Available RORγ Inverse Agonist.

Wu X, Shen H, Zhang Y, Wang C, Li Q, Zhang C, Zhuang X, Li C, Shi Y, Xing Y, Xiang Q, Xu J, Wu D, Liu J, Xu Y. Wu X, et al. Among authors: li c, li q. J Med Chem. 2021 Jun 24;64(12):8775-8797. doi: 10.1021/acs.jmedchem.1c00763. Epub 2021 Jun 14. J Med Chem. 2021. PMID: 34121397

8

Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives.

Zhao PL, Chen P, Li Q, Hu MJ, Diao PC, Pan ES, You WW. Zhao PL, et al. Among authors: li q. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3679-83. doi: 10.1016/j.bmcl.2016.05.086. Epub 2016 May 28. Bioorg Med Chem Lett. 2016. PMID: 27287368

9

Discovery and Characterization of XY101, a Potent, Selective, and Orally Bioavailable RORγ Inverse Agonist for Treatment of Castration-Resistant Prostate Cancer.

Zhang Y, Wu X, Xue X, Li C, Wang J, Wang R, Zhang C, Wang C, Shi Y, Zou L, Li Q, Huang Z, Hao X, Loomes K, Wu D, Chen HW, Xu J, Xu Y. Zhang Y, et al. Among authors: li c, li q. J Med Chem. 2019 May 9;62(9):4716-4730. doi: 10.1021/acs.jmedchem.9b00327. Epub 2019 Apr 22. J Med Chem. 2019. PMID: 30964293

10

Design, synthesis and antiproliferative activity of novel 2,4-diamino-5-methyleneaminopyrimidine derivatives as potential anticancer agents.

Li Q, Chen L, Jian XE, Lv DX, You WW, Zhao PL. Li Q, et al. Bioorg Med Chem Lett. 2021 Sep 1;47:128213. doi: 10.1016/j.bmcl.2021.128213. Epub 2021 Jun 19. Bioorg Med Chem Lett. 2021. PMID: 34157389

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