Hydroxypyridonecarboxylic Acids as Inhibitors of Human Cytomegalovirus pUL89 Endonuclease.
Kankanala J, Wang Y, Geraghty RJ, Wang Z.
Kankanala J, et al.
ChemMedChem. 2018 Aug 20;13(16):1658-1663. doi: 10.1002/cmdc.201800283. Epub 2018 Jul 20.
ChemMedChem. 2018.
PMID: 29968426
However, inhibitors of the endonuclease activity of the C terminus of pUL89 (pUL89-C) were unknown before our recently characterized hydroxypyridonecarboxylic acid (HPCA) hit 7 r (1-(3-chloro-4-fluorobenzyl)-5-hydroxy-4-oxo-1,4-dihydropyridine-3-carboxylic acid; numbered as 10 k …
However, inhibitors of the endonuclease activity of the C terminus of pUL89 (pUL89-C) were unknown before our recently characterized hydroxy …