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Structure-Guided Conformational Restriction Leading to High-Affinity, Selective, and Cell-Active Tetrahydroisoquinoline-Based Noncovalent Keap1-Nrf2 Inhibitors.
Qin Y, Poulsen C, Narayanan D, Chan CB, Chen X, Montes BR, Tran KT, Mukminova E, Lin C, Gajhede M, Bullock AN, Olagnier D, Bach A. Qin Y, et al. Among authors: olagnier d. J Med Chem. 2024 Nov 14;67(21):18828-18864. doi: 10.1021/acs.jmedchem.4c01221. Epub 2024 Oct 17. J Med Chem. 2024. PMID: 39418396
VPS34-dependent control of apical membrane function of proximal tubule cells and nutrient recovery by the kidney.
Rinschen MM, Harder JL, Carter-Timofte ME, Zanon Rodriguez L, Mirabelli C, Demir F, Kurmasheva N, Ramakrishnan SK, Kunke M, Tan Y, Billing A, Dahlke E, Larionov AA, Bechtel-Walz W, Aukschun U, Grabbe M, Nielsen R, Christensen EI, Kretzler M, Huber TB, Wobus CE, Olagnier D, Siuzdak G, Grahammer F, Theilig F. Rinschen MM, et al. Among authors: olagnier d. Sci Signal. 2022 Nov 29;15(762):eabo7940. doi: 10.1126/scisignal.abo7940. Epub 2022 Nov 29. Sci Signal. 2022. PMID: 36445937 Free PMC article.
Systems analysis of a RIG-I agonist inducing broad spectrum inhibition of virus infectivity.
Goulet ML, Olagnier D, Xu Z, Paz S, Belgnaoui SM, Lafferty EI, Janelle V, Arguello M, Paquet M, Ghneim K, Richards S, Smith A, Wilkinson P, Cameron M, Kalinke U, Qureshi S, Lamarre A, Haddad EK, Sekaly RP, Peri S, Balachandran S, Lin R, Hiscott J. Goulet ML, et al. Among authors: olagnier d. PLoS Pathog. 2013;9(4):e1003298. doi: 10.1371/journal.ppat.1003298. Epub 2013 Apr 25. PLoS Pathog. 2013. PMID: 23633948 Free PMC article.
86 results