Lewis EA - Search Results

1

Alkyne-substituted diminazene as G-quadruplex binders with anticancer activities.

Wang C, Carter-Cooper B, Du Y, Zhou J, Saeed MA, Liu J, Guo M, Roembke B, Mikek C, Lewis EA, Lapidus RG, Sintim HO. Wang C, et al. Among authors: lewis ea. Eur J Med Chem. 2016 Aug 8;118:266-75. doi: 10.1016/j.ejmech.2016.04.030. Epub 2016 Apr 20. Eur J Med Chem. 2016. PMID: 27132164

2

Diminazene or berenil, a classic duplex minor groove binder, binds to G-quadruplexes with low nanomolar dissociation constants and the amidine groups are also critical for G-quadruplex binding.

Zhou J, Le V, Kalia D, Nakayama S, Mikek C, Lewis EA, Sintim HO. Zhou J, et al. Among authors: lewis ea. Mol Biosyst. 2014 Oct;10(10):2724-34. doi: 10.1039/c4mb00359d. Mol Biosyst. 2014. PMID: 25096593

3

Berenil Binds Tightly to Parallel and Mixed Parallel/Antiparallel G-Quadruplex Motifs with Varied Thermodynamic Signatures.

Mikek CG, West SJ, Gwin JC, Dayal N, Sintim HO, Lewis EA. Mikek CG, et al. Among authors: lewis ea. ACS Omega. 2018 Sep 30;3(9):11582-11591. doi: 10.1021/acsomega.8b01621. Epub 2018 Sep 21. ACS Omega. 2018. PMID: 30320266 Free PMC article.

4

Temperature and osmotic stress dependence of the thermodynamics for binding linker histone H1⁰, Its carboxyl domain (H1⁰-C) or globular domain (H1⁰-G) to B-DNA.

Machha VR, Mikek CG, Wellman S, Lewis EA. Machha VR, et al. Among authors: lewis ea. Biochem Biophys Rep. 2017 Oct 13;12:158-165. doi: 10.1016/j.bbrep.2017.09.009. eCollection 2017 Dec. Biochem Biophys Rep. 2017. PMID: 29090277 Free PMC article.

5

The effect of pyridyl substituents on the thermodynamics of porphyrin binding to G-quadruplex DNA.

Rowland GB, Barnett K, Dupont JI, Akurathi G, Le VH, Lewis EA. Rowland GB, et al. Among authors: lewis ea. Bioorg Med Chem. 2013 Dec 1;21(23):7515-22. doi: 10.1016/j.bmc.2013.09.036. Epub 2013 Sep 21. Bioorg Med Chem. 2013. PMID: 24148836

6

DSC deconvolution of the structural complexity of c-MYC P1 promoter G-quadruplexes.

Dettler JM, Buscaglia R, Le VH, Lewis EA. Dettler JM, et al. Among authors: lewis ea. Biophys J. 2011 Mar 16;100(6):1517-25. doi: 10.1016/j.bpj.2011.01.068. Biophys J. 2011. PMID: 21402034 Free PMC article.

7

Bcl-2 promoter sequence G-quadruplex interactions with three planar and non-planar cationic porphyrins: TMPyP4, TMPyP3, and TMPyP2.

Le VH, Nagesh N, Lewis EA. Le VH, et al. Among authors: lewis ea. PLoS One. 2013 Aug 20;8(8):e72462. doi: 10.1371/journal.pone.0072462. eCollection 2013. PLoS One. 2013. PMID: 23977303 Free PMC article.

8

Biophysical characterization of an ensemble of intramolecular i-motifs formed by the human c-MYC NHE III1 P1 promoter mutant sequence.

Dettler JM, Buscaglia R, Cui J, Cashman D, Blynn M, Lewis EA. Dettler JM, et al. Among authors: lewis ea. Biophys J. 2010 Jul 21;99(2):561-7. doi: 10.1016/j.bpj.2010.04.042. Biophys J. 2010. PMID: 20643075 Free PMC article.

9

Exploring the energetics of histone H1.1 and H1.4 duplex DNA interactions.

Machha VR, Jones SB, Waddle JR, Le VH, Wellman S, Lewis EA. Machha VR, et al. Among authors: lewis ea. Biophys Chem. 2014 Jan;185:32-8. doi: 10.1016/j.bpc.2013.11.007. Epub 2013 Nov 26. Biophys Chem. 2014. PMID: 24317196

10

Calorimetric and spectroscopic investigations of the binding of metallated porphyrins to G-quadruplex DNA.

DuPont JI, Henderson KL, Metz A, Le VH, Emerson JP, Lewis EA. DuPont JI, et al. Among authors: lewis ea. Biochim Biophys Acta. 2016 May;1860(5):902-909. doi: 10.1016/j.bbagen.2015.09.004. Epub 2015 Sep 9. Biochim Biophys Acta. 2016. PMID: 26363462

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