RasGRP1 stimulation enhances ubiquitination and endocytosis of the sodium-chloride cotransporter.
Ko B, Kamsteeg EJ, Cooke LL, Moddes LN, Deen PM, Hoover RS.
Ko B, et al. Among authors: hoover rs.
Am J Physiol Renal Physiol. 2010 Aug;299(2):F300-9. doi: 10.1152/ajprenal.00441.2009. Epub 2010 Apr 14.
Am J Physiol Renal Physiol. 2010.
PMID: 20392800
Free PMC article.
Recently, we described a novel pathway of NCC regulation in which phorbol esters (PE) stimulate Ras guanyl-releasing protein 1 (RasGRP1), triggering a cascade ultimately activating ERK1/2 MAPK and decreasing NCC cell surface expression (Ko B, Joshi LM, Cooke LL, Vazquez N, Musch …
Recently, we described a novel pathway of NCC regulation in which phorbol esters (PE) stimulate Ras guanyl-releasing protein 1 (RasGRP1), tr …