Cohen P - Search Results

1

HCK is a survival determinant transactivated by mutated MYD88, and a direct target of ibrutinib.

Yang G, Buhrlage SJ, Tan L, Liu X, Chen J, Xu L, Tsakmaklis N, Chen JG, Patterson CJ, Brown JR, Castillo JJ, Zhang W, Zhang X, Liu S, Cohen P, Hunter ZR, Gray N, Treon SP. Yang G, et al. Among authors: cohen p. Blood. 2016 Jun 23;127(25):3237-52. doi: 10.1182/blood-2016-01-695098. Epub 2016 May 3. Blood. 2016. PMID: 27143257 Free article.

2

Essential role for IKKβ in production of type 1 interferons by plasmacytoid dendritic cells.

Pauls E, Shpiro N, Peggie M, Young ER, Sorcek RJ, Tan L, Choi HG, Cohen P. Pauls E, et al. Among authors: cohen p. J Biol Chem. 2012 Jun 1;287(23):19216-28. doi: 10.1074/jbc.M112.345405. Epub 2012 Apr 16. J Biol Chem. 2012. PMID: 22511786 Free PMC article.

3

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling.

Dzamko N, Inesta-Vaquera F, Zhang J, Xie C, Cai H, Arthur S, Tan L, Choi H, Gray N, Cohen P, Pedrioli P, Clark K, Alessi DR. Dzamko N, et al. Among authors: cohen p. PLoS One. 2012;7(6):e39132. doi: 10.1371/journal.pone.0039132. Epub 2012 Jun 18. PLoS One. 2012. PMID: 22723946 Free PMC article.

4

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.

Clark K, MacKenzie KF, Petkevicius K, Kristariyanto Y, Zhang J, Choi HG, Peggie M, Plater L, Pedrioli PG, McIver E, Gray NS, Arthur JS, Cohen P. Clark K, et al. Among authors: cohen p. Proc Natl Acad Sci U S A. 2012 Oct 16;109(42):16986-91. doi: 10.1073/pnas.1215450109. Epub 2012 Oct 2. Proc Natl Acad Sci U S A. 2012. PMID: 23033494 Free PMC article.

5

Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).

Tan L, Nomanbhoy T, Gurbani D, Patricelli M, Hunter J, Geng J, Herhaus L, Zhang J, Pauls E, Ham Y, Choi HG, Xie T, Deng X, Buhrlage SJ, Sim T, Cohen P, Sapkota G, Westover KD, Gray NS. Tan L, et al. Among authors: cohen p. J Med Chem. 2015 Jan 8;58(1):183-96. doi: 10.1021/jm500480k. Epub 2014 Jul 30. J Med Chem. 2015. PMID: 25075558 Free PMC article.

6

Protein kinase IKKβ-catalyzed phosphorylation of IRF5 at Ser462 induces its dimerization and nuclear translocation in myeloid cells.

Lopez-Pelaez M, Lamont DJ, Peggie M, Shpiro N, Gray NS, Cohen P. Lopez-Pelaez M, et al. Among authors: cohen p. Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17432-7. doi: 10.1073/pnas.1418399111. Epub 2014 Oct 17. Proc Natl Acad Sci U S A. 2014. PMID: 25326418 Free PMC article.

7

Suppression of interferon β gene transcription by inhibitors of bromodomain and extra-terminal (BET) family members.

Malik N, Vollmer S, Nanda SK, Lopez-Pelaez M, Prescott A, Gray N, Cohen P. Malik N, et al. Among authors: cohen p. Biochem J. 2015 Jun 15;468(3):363-72. doi: 10.1042/BJ20141523. Epub 2015 Apr 20. Biochem J. 2015. PMID: 25891802 Free PMC article.

8

The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists.

Vollmer S, Strickson S, Zhang T, Gray N, Lee KL, Rao VR, Cohen P. Vollmer S, et al. Among authors: cohen p. Biochem J. 2017 Jun 6;474(12):2027-2038. doi: 10.1042/BCJ20170097. Biochem J. 2017. PMID: 28512203 Free PMC article.

9

Novel cross-talk within the IKK family controls innate immunity.

Clark K, Peggie M, Plater L, Sorcek RJ, Young ER, Madwed JB, Hough J, McIver EG, Cohen P. Clark K, et al. Among authors: cohen p. Biochem J. 2011 Feb 15;434(1):93-104. doi: 10.1042/BJ20101701. Biochem J. 2011. PMID: 21138416

10

Identification of the protein kinases that activate the E3 ubiquitin ligase Pellino 1 in the innate immune system.

Goh ET, Arthur JS, Cheung PC, Akira S, Toth R, Cohen P. Goh ET, et al. Among authors: cohen p. Biochem J. 2012 Jan 1;441(1):339-46. doi: 10.1042/BJ20111415. Biochem J. 2012. PMID: 22007846

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