Rotty JD - Search Results

1

Lamellipodia are crucial for haptotactic sensing and response.

King SJ, Asokan SB, Haynes EM, Zimmerman SP, Rotty JD, Alb JG Jr, Tagliatela A, Blake DR, Lebedeva IP, Marston D, Johnson HE, Parsons M, Sharpless NE, Kuhlman B, Haugh JM, Bear JE. King SJ, et al. Among authors: rotty jd. J Cell Sci. 2016 Jun 15;129(12):2329-42. doi: 10.1242/jcs.184507. Epub 2016 May 12. J Cell Sci. 2016. PMID: 27173494 Free PMC article.

2

New insights into the regulation and cellular functions of the ARP2/3 complex.

Rotty JD, Wu C, Bear JE. Rotty JD, et al. Nat Rev Mol Cell Biol. 2013 Jan;14(1):7-12. doi: 10.1038/nrm3492. Epub 2012 Dec 5. Nat Rev Mol Cell Biol. 2013. PMID: 23212475 Review.

3

Mesenchymal chemotaxis requires selective inactivation of myosin II at the leading edge via a noncanonical PLCγ/PKCα pathway.

Asokan SB, Johnson HE, Rahman A, King SJ, Rotty JD, Lebedeva IP, Haugh JM, Bear JE. Asokan SB, et al. Among authors: rotty jd. Dev Cell. 2014 Dec 22;31(6):747-60. doi: 10.1016/j.devcel.2014.10.024. Epub 2014 Dec 4. Dev Cell. 2014. PMID: 25482883 Free PMC article.

4

Profilin-1 serves as a gatekeeper for actin assembly by Arp2/3-dependent and -independent pathways.

Rotty JD, Wu C, Haynes EM, Suarez C, Winkelman JD, Johnson HE, Haugh JM, Kovar DR, Bear JE. Rotty JD, et al. Dev Cell. 2015 Jan 12;32(1):54-67. doi: 10.1016/j.devcel.2014.10.026. Epub 2014 Dec 24. Dev Cell. 2015. PMID: 25543281 Free PMC article.

5

F-actin bundles direct the initiation and orientation of lamellipodia through adhesion-based signaling.

Johnson HE, King SJ, Asokan SB, Rotty JD, Bear JE, Haugh JM. Johnson HE, et al. Among authors: rotty jd. J Cell Biol. 2015 Feb 16;208(4):443-55. doi: 10.1083/jcb.201406102. Epub 2015 Feb 9. J Cell Biol. 2015. PMID: 25666809 Free PMC article.

6

Competition and collaboration between different actin assembly pathways allows for homeostatic control of the actin cytoskeleton.

Rotty JD, Bear JE. Rotty JD, et al. Bioarchitecture. 2014;5(1-2):27-34. doi: 10.1080/19490992.2015.1090670. Epub 2015 Oct 2. Bioarchitecture. 2014. PMID: 26430713 Free PMC article.

7

Arp2/3 Complex Is Required for Macrophage Integrin Functions but Is Dispensable for FcR Phagocytosis and In Vivo Motility.

Rotty JD, Brighton HE, Craig SL, Asokan SB, Cheng N, Ting JP, Bear JE. Rotty JD, et al. Dev Cell. 2017 Sep 11;42(5):498-513.e6. doi: 10.1016/j.devcel.2017.08.003. Epub 2017 Aug 31. Dev Cell. 2017. PMID: 28867487 Free PMC article.

8

Lack of myeloid Fatp1 increases atherosclerotic lesion size in Ldlr^-/- mice.

Zhao L, Cozzo AJ, Johnson AR, Christensen T, Freemerman AJ, Bear JE, Rotty JD, Bennett BJ, Makowski L. Zhao L, et al. Among authors: rotty jd. Atherosclerosis. 2017 Nov;266:182-189. doi: 10.1016/j.atherosclerosis.2017.10.009. Epub 2017 Oct 7. Atherosclerosis. 2017. PMID: 29035781 Free PMC article.

9

Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.

Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W. Paul DS, et al. Among authors: rotty jd. Blood Adv. 2017 Aug 8;1(18):1398-1408. doi: 10.1182/bloodadvances.2017006973. Blood Adv. 2017. PMID: 29104956 Free PMC article.

10

Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation.

Tessier S, Doolittle AC, Sao K, Rotty JD, Bear JE, Ulici V, Loeser RF, Shapiro IM, Diekman BO, Risbud MV. Tessier S, et al. Among authors: rotty jd. JCI Insight. 2020 Feb 27;5(4):e131382. doi: 10.1172/jci.insight.131382. JCI Insight. 2020. PMID: 31961823 Free PMC article.

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