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Heritability of ECG Biomarkers in the Netherlands Twin Registry Measured from Holter ECGs.
Hodkinson EC, Neijts M, Sadrieh A, Imtiaz MS, Baumert M, Subbiah RN, Hayward CS, Boomsma D, Willemsen G, Vandenberg JI, Hill AP, De Geus E. Hodkinson EC, et al. Among authors: vandenberg ji. Front Physiol. 2016 Apr 29;7:154. doi: 10.3389/fphys.2016.00154. eCollection 2016. Front Physiol. 2016. PMID: 27199769 Free PMC article.
Not all hERG pore domain mutations have a severe phenotype: G584S has an inactivation gating defect with mild phenotype compared to G572S, which has a dominant negative trafficking defect and a severe phenotype.
Zhao JT, Hill AP, Varghese A, Cooper AA, Swan H, Laitinen-Forsblom PJ, Rees MI, Skinner JR, Campbell TJ, Vandenberg JI. Zhao JT, et al. Among authors: vandenberg ji. J Cardiovasc Electrophysiol. 2009 Aug;20(8):923-30. doi: 10.1111/j.1540-8167.2009.01468.x. Epub 2009 Apr 10. J Cardiovasc Electrophysiol. 2009. PMID: 19490267
154 results