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Page 1
Protein-Protein Interaction Inhibition (2P2I)-Oriented Chemical Library Accelerates Hit Discovery.
Milhas S, Raux B, Betzi S, Derviaux C, Roche P, Restouin A, Basse MJ, Rebuffet E, Lugari A, Badol M, Kashyap R, Lissitzky JC, Eydoux C, Hamon V, Gourdel ME, Combes S, Zimmermann P, Aurrand-Lions M, Roux T, Rogers C, Müller S, Knapp S, Trinquet E, Collette Y, Guillemot JC, Morelli X. Milhas S, et al. Among authors: guillemot jc. ACS Chem Biol. 2016 Aug 19;11(8):2140-8. doi: 10.1021/acschembio.6b00286. Epub 2016 Jun 3. ACS Chem Biol. 2016. PMID: 27219844
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins.
Raux B, Voitovich Y, Derviaux C, Lugari A, Rebuffet E, Milhas S, Priet S, Roux T, Trinquet E, Guillemot JC, Knapp S, Brunel JM, Fedorov AY, Collette Y, Roche P, Betzi S, Combes S, Morelli X. Raux B, et al. Among authors: guillemot jc. J Med Chem. 2016 Feb 25;59(4):1634-41. doi: 10.1021/acs.jmedchem.5b01708. Epub 2016 Jan 6. J Med Chem. 2016. PMID: 26735842
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes.
Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I, Canard B, Guillemot JC, Lécine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X. Bouvet M, et al. Among authors: guillemot jc. J Biol Chem. 2014 Sep 12;289(37):25783-96. doi: 10.1074/jbc.M114.577353. Epub 2014 Jul 29. J Biol Chem. 2014. PMID: 25074927 Free PMC article.
Molecular mapping of the RNA Cap 2'-O-methyltransferase activation interface between severe acute respiratory syndrome coronavirus nsp10 and nsp16.
Lugari A, Betzi S, Decroly E, Bonnaud E, Hermant A, Guillemot JC, Debarnot C, Borg JP, Bouvet M, Canard B, Morelli X, Lécine P. Lugari A, et al. Among authors: guillemot jc. J Biol Chem. 2010 Oct 22;285(43):33230-33241. doi: 10.1074/jbc.M110.120014. Epub 2010 Aug 10. J Biol Chem. 2010. PMID: 20699222 Free PMC article.
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.
Betzi S, Eydoux C, Bussetta C, Blemont M, Leyssen P, Debarnot C, Ben-Rahou M, Haiech J, Hibert M, Gueritte F, Grierson DS, Romette JL, Guillemot JC, Neyts J, Alvarez K, Morelli X, Dutartre H, Canard B. Betzi S, et al. Among authors: guillemot jc. Antiviral Res. 2009 Oct;84(1):48-59. doi: 10.1016/j.antiviral.2009.06.009. Epub 2009 Jul 7. Antiviral Res. 2009. PMID: 19589358
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase.
Benmansour F, Eydoux C, Querat G, de Lamballerie X, Canard B, Alvarez K, Guillemot JC, Barral K. Benmansour F, et al. Among authors: guillemot jc. Eur J Med Chem. 2016 Feb 15;109:146-56. doi: 10.1016/j.ejmech.2015.12.046. Epub 2015 Dec 29. Eur J Med Chem. 2016. PMID: 26774922
111 results