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Everolimus induces Met inactivation by disrupting the FKBP12/Met complex.
Raimondo L, D'Amato V, Servetto A, Rosa R, Marciano R, Formisano L, Di Mauro C, Orsini RC, Cascetta P, Ciciola P, De Maio AP, Di Renzo MF, Cosconati S, Bruno A, Randazzo A, Napolitano F, Montuori N, Veneziani BM, De Placido S, Bianco R. Raimondo L, et al. Among authors: bruno a. Oncotarget. 2016 Jun 28;7(26):40073-40084. doi: 10.18632/oncotarget.9484. Oncotarget. 2016. PMID: 27223077 Free PMC article.
Deepening the Topology of the Translocator Protein Binding Site by Novel N,N-Dialkyl-2-arylindol-3-ylglyoxylamides.
Barresi E, Bruno A, Taliani S, Cosconati S, Da Pozzo E, Salerno S, Simorini F, Daniele S, Giacomelli C, Marini AM, La Motta C, Marinelli L, Cosimelli B, Novellino E, Greco G, Da Settimo F, Martini C. Barresi E, et al. Among authors: bruno a. J Med Chem. 2015 Aug 13;58(15):6081-92. doi: 10.1021/acs.jmedchem.5b00689. Epub 2015 Jul 28. J Med Chem. 2015. PMID: 26177193
Design, synthesis, and biological evaluation of novel 2-((2-(4-(substituted)phenylpiperazin-1-yl)ethyl)amino)-5'-N-ethylcarboxamidoadenosines as potent and selective agonists of the A2A adenosine receptor.
Preti D, Baraldi PG, Saponaro G, Romagnoli R, Aghazadeh Tabrizi M, Baraldi S, Cosconati S, Bruno A, Novellino E, Vincenzi F, Ravani A, Borea PA, Varani K. Preti D, et al. Among authors: bruno a. J Med Chem. 2015 Apr 9;58(7):3253-67. doi: 10.1021/acs.jmedchem.5b00215. Epub 2015 Mar 25. J Med Chem. 2015. PMID: 25780876
Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors.
Castellano S, Taliani S, Viviano M, Milite C, Da Pozzo E, Costa B, Barresi E, Bruno A, Cosconati S, Marinelli L, Greco G, Novellino E, Sbardella G, Da Settimo F, Martini C. Castellano S, et al. Among authors: bruno a. J Med Chem. 2014 Mar 27;57(6):2413-28. doi: 10.1021/jm401721h. Epub 2014 Mar 17. J Med Chem. 2014. PMID: 24580635
Pharmacological folding chaperones act as allosteric ligands of Frizzled4.
Generoso SF, Giustiniano M, La Regina G, Bottone S, Passacantilli S, Di Maro S, Cassese H, Bruno A, Mallardo M, Dentice M, Silvestri R, Marinelli L, Sarnataro D, Bonatti S, Novellino E, Stornaiuolo M. Generoso SF, et al. Among authors: bruno a. Nat Chem Biol. 2015 Apr;11(4):280-6. doi: 10.1038/nchembio.1770. Epub 2015 Mar 9. Nat Chem Biol. 2015. PMID: 25751279
Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain relief.
Moriconi A, Cunha TM, Souza GR, Lopes AH, Cunha FQ, Carneiro VL, Pinto LG, Brandolini L, Aramini A, Bizzarri C, Bianchini G, Beccari AR, Fanton M, Bruno A, Costantino G, Bertini R, Galliera E, Locati M, Ferreira SH, Teixeira MM, Allegretti M. Moriconi A, et al. Among authors: bruno a. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16937-42. doi: 10.1073/pnas.1417365111. Epub 2014 Nov 10. Proc Natl Acad Sci U S A. 2014. PMID: 25385614 Free PMC article.
Structure-based optimization of tyrosine kinase inhibitor CLM3. Design, synthesis, functional evaluation, and molecular modeling studies.
Sartini S, Coviello V, Bruno A, La Pietra V, Marinelli L, Simorini F, Taliani S, Salerno S, Marini AM, Fioravanti A, Orlandi P, Antonelli A, Da Settimo F, Novellino E, Bocci G, La Motta C. Sartini S, et al. Among authors: bruno a. J Med Chem. 2014 Feb 27;57(4):1225-35. doi: 10.1021/jm401358b. Epub 2014 Feb 5. J Med Chem. 2014. PMID: 24447248
1,594 results