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Omega-6 polyunsaturated fatty acid gamma-linolenic acid (18:3n-6) is a selective estrogen-response modulator in human breast cancer cells: gamma-linolenic acid antagonizes estrogen receptor-dependent transcriptional activity, transcriptionally represses estrogen receptor expression and synergistically enhances tamoxifen and ICI 182,780 (Faslodex) efficacy in human breast cancer cells.
Menendez JA, Colomer R, Lupu R. Menendez JA, et al. Among authors: lupu r. Int J Cancer. 2004 May 10;109(6):949-54. doi: 10.1002/ijc.20096. Int J Cancer. 2004. PMID: 15027132 No abstract available.
Overexpression and hyperactivity of breast cancer-associated fatty acid synthase (oncogenic antigen-519) is insensitive to normal arachidonic fatty acid-induced suppression in lipogenic tissues but it is selectively inhibited by tumoricidal alpha-linolenic and gamma-linolenic fatty acids: a novel mechanism by which dietary fat can alter mammary tumorigenesis.
Menendez JA, Ropero S, Mehmi I, Atlas E, Colomer R, Lupu R. Menendez JA, et al. Among authors: lupu r. Int J Oncol. 2004 Jun;24(6):1369-83. Int J Oncol. 2004. PMID: 15138577
167 results