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Novel mutations in RASGRP2, which encodes CalDAG-GEFI, abrogate Rap1 activation, causing platelet dysfunction.
Lozano ML, Cook A, Bastida JM, Paul DS, Iruin G, Cid AR, Adan-Pedroso R, Ramón González-Porras J, Hernández-Rivas JM, Fletcher SJ, Johnson B, Morgan N, Ferrer-Marin F, Vicente V, Sondek J, Watson SP, Bergmeier W, Rivera J. Lozano ML, et al. Among authors: bergmeier w. Blood. 2016 Sep 1;128(9):1282-9. doi: 10.1182/blood-2015-11-683102. Epub 2016 May 27. Blood. 2016. PMID: 27235135 Free PMC article. Clinical Trial.
Rap1-Rac1 circuits potentiate platelet activation.
Stefanini L, Boulaftali Y, Ouellette TD, Holinstat M, Désiré L, Leblond B, Andre P, Conley PB, Bergmeier W. Stefanini L, et al. Among authors: bergmeier w. Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):434-41. doi: 10.1161/ATVBAHA.111.239194. Epub 2011 Nov 10. Arterioscler Thromb Vasc Biol. 2012. PMID: 22075250 Free PMC article.
RASA3 is a critical inhibitor of RAP1-dependent platelet activation.
Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W. Stefanini L, et al. Among authors: bergmeier w. J Clin Invest. 2015 Apr;125(4):1419-32. doi: 10.1172/JCI77993. Epub 2015 Feb 23. J Clin Invest. 2015. PMID: 25705885 Free PMC article.
Rap1 and its effector RIAM are required for lymphocyte trafficking.
Su W, Wynne J, Pinheiro EM, Strazza M, Mor A, Montenont E, Berger J, Paul DS, Bergmeier W, Gertler FB, Philips MR. Su W, et al. Among authors: bergmeier w. Blood. 2015 Dec 17;126(25):2695-703. doi: 10.1182/blood-2015-05-644104. Epub 2015 Aug 31. Blood. 2015. PMID: 26324702 Free PMC article.
RAP1-GTPase signaling and platelet function.
Stefanini L, Bergmeier W. Stefanini L, et al. Among authors: bergmeier w. J Mol Med (Berl). 2016 Jan;94(1):13-9. doi: 10.1007/s00109-015-1346-3. Epub 2015 Oct 1. J Mol Med (Berl). 2016. PMID: 26423530 Free PMC article. Review.
147 results