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KCa 3.1-a microglial target ready for drug repurposing?
Dale E, Staal RG, Eder C, Möller T. Dale E, et al. Among authors: staal rg. Glia. 2016 Oct;64(10):1733-41. doi: 10.1002/glia.22992. Epub 2016 Apr 28. Glia. 2016. PMID: 27121595 Review.
Senicapoc: Repurposing a Drug to Target Microglia KCa3.1 in Stroke.
Staal RGW, Weinstein JR, Nattini M, Cajina M, Chandresana G, Möller T. Staal RGW, et al. Neurochem Res. 2017 Sep;42(9):2639-2645. doi: 10.1007/s11064-017-2223-y. Epub 2017 Mar 31. Neurochem Res. 2017. PMID: 28364331 Free PMC article. Review.
Synthesis and Characterization of the Novel Rodent-Active and CNS-Penetrant P2X7 Receptor Antagonist Lu AF27139.
Hopper AT, Juhl M, Hornberg J, Badolo L, Kilburn JP, Thougaard A, Smagin G, Song D, Calice L, Menon V, Dale E, Zhang H, Cajina M, Nattini ME, Gandhi A, Grenon M, Jones K, Khayrullina T, Chandrasena G, Thomsen C, Zorn SH, Brodbeck R, Poda SB, Staal R, Möller T. Hopper AT, et al. J Med Chem. 2021 Apr 22;64(8):4891-4902. doi: 10.1021/acs.jmedchem.0c02249. Epub 2021 Apr 6. J Med Chem. 2021. PMID: 33822617
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain.
Staal RGW, Gandhi A, Zhou H, Cajina M, Jacobsen AM, Hestehave S, Hopper A, Poda S, Chandresana G, Zorn SH, Campbell B, Segerdahl M, Mӧller T, Munro G. Staal RGW, et al. Purinergic Signal. 2022 Dec;18(4):499-514. doi: 10.1007/s11302-022-09892-0. Epub 2022 Aug 24. Purinergic Signal. 2022. PMID: 36001278 Free PMC article.
P2X7 receptor-mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats.
Staal R, Khayrullina T, Christensen R, Hestehave S, Zhou H, Cajina M, Nattini ME, Gandhi A, Fallon SM, Schmidt M, Zorn SH, Brodbeck RM, Chandrasena G, Segerdahl M, Breysse N, Hopper AT, Möller T, Munro G. Staal R, et al. Eur J Pain. 2022 Jul;26(6):1304-1321. doi: 10.1002/ejp.1951. Epub 2022 Apr 22. Eur J Pain. 2022. PMID: 35388574
24 results