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Page 1
Phase 2 Study of Trabectedin in Patients With Hormone Receptor-Positive, HER-2-Negative, Advanced Breast Carcinoma According to Expression of Xeroderma Pigmentosum G Gene.
Awada A, Cortés J, Martín M, Aftimos P, Oliveira M, López-Tarruella S, Espie M, Lardelli P, Extremera S, Fernández-García EM, Delaloge S. Awada A, et al. Among authors: extremera s. Clin Breast Cancer. 2016 Oct;16(5):364-371. doi: 10.1016/j.clbc.2016.05.005. Epub 2016 May 14. Clin Breast Cancer. 2016. PMID: 27266804 Clinical Trial.
Plitidepsin has a safe cardiac profile: a comprehensive analysis.
Soto-Matos A, Szyldergemajn S, Extremera S, Miguel-Lillo B, Alfaro V, Coronado C, Lardelli P, Roy E, Corrado CS, Kahatt C. Soto-Matos A, et al. Among authors: extremera s. Mar Drugs. 2011;9(6):1007-1023. doi: 10.3390/md9061007. Epub 2011 Jun 9. Mar Drugs. 2011. PMID: 21747745 Free PMC article. Clinical Trial.
Phase I-II study of plitidepsin and dacarbazine as first-line therapy for advanced melanoma.
Plummer R, Lorigan P, Brown E, Zaucha R, Moiseyenko V, Demidov L, Soriano V, Chmielowska E, Andrés R, Kudryavtseva G, Kahatt C, Szyldergemajn S, Extremera S, de Miguel B, Cullell-Young M, Calvert H. Plummer R, et al. Among authors: extremera s. Br J Cancer. 2013 Sep 17;109(6):1451-9. doi: 10.1038/bjc.2013.477. Epub 2013 Aug 29. Br J Cancer. 2013. PMID: 23989947 Free PMC article. Clinical Trial.
Multicenter phase II study of plitidepsin in patients with relapsed/refractory non-Hodgkin's lymphoma.
Ribrag V, Caballero D, Fermé C, Zucca E, Arranz R, Briones J, Gisselbrecht C, Salles G, Gianni AM, Gomez H, Kahatt C, Corrado C, Szyldergemajn S, Extremera S, de Miguel B, Cullell-Young M, Cavalli F. Ribrag V, et al. Among authors: extremera s. Haematologica. 2013 Mar;98(3):357-63. doi: 10.3324/haematol.2012.069757. Epub 2012 Oct 12. Haematologica. 2013. PMID: 23065525 Free PMC article. Clinical Trial.
Phase II clinical and pharmacokinetic study of plitidepsin 3-hour infusion every two weeks alone or with dexamethasone in relapsed and refractory multiple myeloma.
Mateos MV, Cibeira MT, Richardson PG, Prosper F, Oriol A, de la Rubia J, Lahuerta JJ, García-Sanz R, Extremera S, Szyldergemajn S, Corrado C, Singer H, Mitsiades CS, Anderson KC, Bladé J, San Miguel J. Mateos MV, et al. Among authors: extremera s. Clin Cancer Res. 2010 Jun 15;16(12):3260-9. doi: 10.1158/1078-0432.CCR-10-0469. Epub 2010 Jun 8. Clin Cancer Res. 2010. PMID: 20530693 Clinical Trial.
Randomized phase III study (ADMYRE) of plitidepsin in combination with dexamethasone vs. dexamethasone alone in patients with relapsed/refractory multiple myeloma.
Spicka I, Ocio EM, Oakervee HE, Greil R, Banh RH, Huang SY, D'Rozario JM, Dimopoulos MA, Martínez S, Extremera S, Kahatt C, Alfaro V, Carella AM, Meuleman N, Hájek R, Symeonidis A, Min CK, Cannell P, Ludwig H, Sonneveld P, Mateos MV. Spicka I, et al. Among authors: extremera s. Ann Hematol. 2019 Sep;98(9):2139-2150. doi: 10.1007/s00277-019-03739-2. Epub 2019 Jun 25. Ann Hematol. 2019. PMID: 31240472 Free PMC article. Clinical Trial.
Evaluation of plitidepsin in patients with primary myelofibrosis and post polycythemia vera/essential thrombocythemia myelofibrosis: results of preclinical studies and a phase II clinical trial.
Pardanani A, Tefferi A, Guglielmelli P, Bogani C, Bartalucci N, Rodríguez J, Extremera S, Pérez I, Alfaro V, Vannucchi AM. Pardanani A, et al. Among authors: extremera s. Blood Cancer J. 2015 Mar 13;5(3):e286. doi: 10.1038/bcj.2015.5. Blood Cancer J. 2015. PMID: 25768401 Free PMC article. Clinical Trial.
A phase I safety and efficacy clinical trial of plocabulin and gemcitabine in patients with advanced solid tumors.
Ghalib MH, Pulla MP, De Miguel Luken MJ, de Juan VC, Chaudhary I, Hammami MB, Vikash S, Maitra R, Martinez S, Kahatt C, Extremera S, Fudio S, Goel S. Ghalib MH, et al. Among authors: extremera s. Invest New Drugs. 2024 Oct;42(5):481-491. doi: 10.1007/s10637-024-01458-8. Epub 2024 Aug 3. Invest New Drugs. 2024. PMID: 39096398 Free PMC article. Clinical Trial.