Gaus H - Search Results

1

Conjugation of mono and di-GalNAc sugars enhances the potency of antisense oligonucleotides via ASGR mediated delivery to hepatocytes.

Kinberger GA, Prakash TP, Yu J, Vasquez G, Low A, Chappell A, Schmidt K, Murray HM, Gaus H, Swayze EE, Seth PP. Kinberger GA, et al. Among authors: gaus h. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3690-3. doi: 10.1016/j.bmcl.2016.05.084. Epub 2016 May 28. Bioorg Med Chem Lett. 2016. PMID: 27268307

2

Formation of 4,4'-dimethoxytrityl-C-phosphonate oligonucleotides.

Capaldi DC, Gaus HJ, Carty RL, Moore MN, Turney BJ, Decottignies SD, McArdle JV, Scozzari AN, Ravikumar VT, Krotz AH. Capaldi DC, et al. Among authors: gaus hj. Bioorg Med Chem Lett. 2004 Sep 20;14(18):4683-90. doi: 10.1016/j.bmcl.2004.06.088. Bioorg Med Chem Lett. 2004. PMID: 15324888

3

Trichloroacetaldehyde modified oligonucleotides.

Gaus H, Olsen P, Sooy KV, Rentel C, Turney B, Walker KL, McArdle JV, Capaldi DC. Gaus H, et al. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4118-24. doi: 10.1016/j.bmcl.2005.06.018. Bioorg Med Chem Lett. 2005. PMID: 16002284

4

Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides.

Kurata C, Bradley K, Gaus H, Luu N, Cedillo I, Ravikumar VT, Van Sooy K, McArdle JV, Capaldi DC. Kurata C, et al. Among authors: gaus h. Bioorg Med Chem Lett. 2006 Feb;16(3):607-14. doi: 10.1016/j.bmcl.2005.10.051. Epub 2005 Nov 7. Bioorg Med Chem Lett. 2006. PMID: 16274991

5

Improving RNA interference in mammalian cells by 4'-thio-modified small interfering RNA (siRNA): effect on siRNA activity and nuclease stability when used in combination with 2'-O-alkyl modifications.

Dande P, Prakash TP, Sioufi N, Gaus H, Jarres R, Berdeja A, Swayze EE, Griffey RH, Bhat B. Dande P, et al. Among authors: gaus h. J Med Chem. 2006 Mar 9;49(5):1624-34. doi: 10.1021/jm050822c. J Med Chem. 2006. PMID: 16509579

6

Design, synthesis and evaluation of constrained methoxyethyl (cMOE) and constrained ethyl (cEt) nucleoside analogs.

Seth PP, Siwkowski A, Allerson CR, Vasquez G, Lee S, Prakash TP, Kinberger G, Migawa MT, Gaus H, Bhat B, Swayze EE. Seth PP, et al. Among authors: gaus h. Nucleic Acids Symp Ser (Oxf). 2008;(52):553-4. doi: 10.1093/nass/nrn280. Nucleic Acids Symp Ser (Oxf). 2008. PMID: 18776499

7

Human Dicer binds short single-strand and double-strand RNA with high affinity and interacts with different regions of the nucleic acids.

Lima WF, Murray H, Nichols JG, Wu H, Sun H, Prakash TP, Berdeja AR, Gaus HJ, Crooke ST. Lima WF, et al. Among authors: gaus hj. J Biol Chem. 2009 Jan 23;284(4):2535-48. doi: 10.1074/jbc.M803748200. Epub 2008 Nov 18. J Biol Chem. 2009. PMID: 19017633 Free article.

8

Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models.

Prakash TP, Siwkowski A, Allerson CR, Migawa MT, Lee S, Gaus HJ, Black C, Seth PP, Swayze EE, Bhat B. Prakash TP, et al. J Med Chem. 2010 Feb 25;53(4):1636-50. doi: 10.1021/jm9013295. J Med Chem. 2010. PMID: 20108935

9

Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

Seth PP, Vasquez G, Allerson CA, Berdeja A, Gaus H, Kinberger GA, Prakash TP, Migawa MT, Bhat B, Swayze EE. Seth PP, et al. Among authors: gaus h. J Org Chem. 2010 Mar 5;75(5):1569-81. doi: 10.1021/jo902560f. J Org Chem. 2010. PMID: 20136157

10

Peptide nucleic acids conjugated to short basic peptides show improved pharmacokinetics and antisense activity in adipose tissue.

Wancewicz EV, Maier MA, Siwkowski AM, Albertshofer K, Winger TM, Berdeja A, Gaus H, Vickers TA, Bennett CF, Monia BP, Griffey RH, Nulf CJ, Hu J, Corey DR, Swayze EE, Kinberger GA. Wancewicz EV, et al. Among authors: gaus h. J Med Chem. 2010 May 27;53(10):3919-26. doi: 10.1021/jm901489k. J Med Chem. 2010. PMID: 20420385 Free PMC article.

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