Graham MJ - Search Results

1

Antisense-Mediated Lowering of Plasma Apolipoprotein C-III by Volanesorsen Improves Dyslipidemia and Insulin Sensitivity in Type 2 Diabetes.

Digenio A, Dunbar RL, Alexander VJ, Hompesch M, Morrow L, Lee RG, Graham MJ, Hughes SG, Yu R, Singleton W, Baker BF, Bhanot S, Crooke RM. Digenio A, et al. Among authors: graham mj. Diabetes Care. 2016 Aug;39(8):1408-15. doi: 10.2337/dc16-0126. Epub 2016 Jun 6. Diabetes Care. 2016. PMID: 27271183 Clinical Trial.

2

In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides.

Crooke RM, Graham MJ, Cooke ME, Crooke ST. Crooke RM, et al. Among authors: graham mj. J Pharmacol Exp Ther. 1995 Oct;275(1):462-73. J Pharmacol Exp Ther. 1995. PMID: 7562586

3

Tritium labeling of antisense oligonucleotides by exchange with tritiated water.

Graham MJ, Freier SM, Crooke RM, Ecker DJ, Maslova RN, Lesnik EA. Graham MJ, et al. Nucleic Acids Res. 1993 Aug 11;21(16):3737-43. doi: 10.1093/nar/21.16.3737. Nucleic Acids Res. 1993. PMID: 8367289 Free PMC article.

4

Effect of antisense oligonucleotides on cytokine release from human keratinocytes in an in vitro model of skin.

Crooke RM, Crooke ST, Graham MJ, Cooke ME. Crooke RM, et al. Among authors: graham mj. Toxicol Appl Pharmacol. 1996 Sep;140(1):85-93. doi: 10.1006/taap.1996.0200. Toxicol Appl Pharmacol. 1996. PMID: 8806873

5

In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration.

Graham MJ, Crooke ST, Monteith DK, Cooper SR, Lemonidis KM, Stecker KK, Martin MJ, Crooke RM. Graham MJ, et al. J Pharmacol Exp Ther. 1998 Jul;286(1):447-58. J Pharmacol Exp Ther. 1998. PMID: 9655890

6

Metabolism of antisense oligonucleotides in rat liver homogenates.

Crooke RM, Graham MJ, Martin MJ, Lemonidis KM, Wyrzykiewiecz T, Cummins LL. Crooke RM, et al. Among authors: graham mj. J Pharmacol Exp Ther. 2000 Jan;292(1):140-9. J Pharmacol Exp Ther. 2000. PMID: 10604941

7

Phosphorothioate oligodeoxynucleotides distribute similarly in class A scavenger receptor knockout and wild-type mice.

Butler M, Crooke RM, Graham MJ, Lemonidis KM, Lougheed M, Murray SF, Witchell D, Steinbrecher U, Bennett CF. Butler M, et al. Among authors: graham mj. J Pharmacol Exp Ther. 2000 Feb;292(2):489-96. J Pharmacol Exp Ther. 2000. PMID: 10640284

8

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

Yu RZ, Zhang H, Geary RS, Graham M, Masarjian L, Lemonidis K, Crooke R, Dean NM, Levin AA. Yu RZ, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):388-95. J Pharmacol Exp Ther. 2001. PMID: 11160622

9

Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration.

Graham MJ, Crooke ST, Lemonidis KM, Gaus HJ, Templin MV, Crooke RM. Graham MJ, et al. Biochem Pharmacol. 2001 Aug 1;62(3):297-306. doi: 10.1016/s0006-2952(01)00669-4. Biochem Pharmacol. 2001. PMID: 11434902

10

An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis.

Crooke RM, Graham MJ, Lemonidis KM, Whipple CP, Koo S, Perera RJ. Crooke RM, et al. Among authors: graham mj. J Lipid Res. 2005 May;46(5):872-84. doi: 10.1194/jlr.M400492-JLR200. Epub 2005 Feb 16. J Lipid Res. 2005. PMID: 15716585 Free article.

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