Gaillard P - Search Results

1

Patient-reported adverse effects of high-dose intravenous methylprednisolone treatment: a prospective web-based multi-center study in multiple sclerosis patients with a relapse.

Jongen PJ, Stavrakaki I, Voet B, Hoogervorst E, van Munster E, Linssen WH, Sinnige LG, Verhagen WI, Visser LH, van der Kruijk R, Verheul F, Boringa J, Heerings M, Gladdines W, Lönnqvist F, Gaillard P. Jongen PJ, et al. Among authors: gaillard p. J Neurol. 2016 Aug;263(8):1641-51. doi: 10.1007/s00415-016-8183-3. Epub 2016 Jun 7. J Neurol. 2016. PMID: 27272956 Free PMC article.

2

Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.

Kanhai KMS, Zuiker RGJA, Stavrakaki I, Gladdines W, Gaillard PJ, Klaassen ES, Groeneveld GJ. Kanhai KMS, et al. Among authors: gaillard pj. Br J Clin Pharmacol. 2018 May;84(5):1020-1028. doi: 10.1111/bcp.13525. Epub 2018 Mar 9. Br J Clin Pharmacol. 2018. PMID: 29385232 Free PMC article. Clinical Trial.

3

Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis.

Lee DH, Rötger C, Appeldoorn CC, Reijerkerk A, Gladdines W, Gaillard PJ, Linker RA. Lee DH, et al. J Neuroimmunol. 2014 Sep 15;274(1-2):96-101. doi: 10.1016/j.jneuroim.2014.06.025. Epub 2014 Jul 6. J Neuroimmunol. 2014. PMID: 25037177

4

Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3-101) as compared with generic Caelyx,(®)/Doxil(®)--a cerebral open flow microperfusion pilot study.

Birngruber T, Raml R, Gladdines W, Gatschelhofer C, Gander E, Ghosh A, Kroath T, Gaillard PJ, Pieber TR, Sinner F. Birngruber T, et al. J Pharm Sci. 2014 Jul;103(7):1945-1948. doi: 10.1002/jps.23994. Epub 2014 May 6. J Pharm Sci. 2014. PMID: 24801480

5

Enhanced brain delivery of liposomal methylprednisolone improved therapeutic efficacy in a model of neuroinflammation.

Gaillard PJ, Appeldoorn CC, Rip J, Dorland R, van der Pol SM, Kooij G, de Vries HE, Reijerkerk A. Gaillard PJ, et al. J Control Release. 2012 Dec 28;164(3):364-9. doi: 10.1016/j.jconrel.2012.06.022. Epub 2012 Jun 23. J Control Release. 2012. PMID: 22732475

6

Systemic treatment with glutathione PEGylated liposomal methylprednisolone (2B3-201) improves therapeutic efficacy in a model of ocular inflammation.

Reijerkerk A, Appeldoorn CC, Rip J, de Boer M, Gaillard PJ. Reijerkerk A, et al. Invest Ophthalmol Vis Sci. 2014 Apr 28;55(4):2788-94. doi: 10.1167/iovs.13-13599. Invest Ophthalmol Vis Sci. 2014. PMID: 24692123

7

Glutathione pegylated liposomal methylprednisolone administration after the early phase of status epilepticus did not modify epileptogenesis in the rat.

Holtman L, van Vliet EA, Appeldoorn C, Gaillard PJ, de Boer M, Dorland R, Wadman WJ, Gorter JA. Holtman L, et al. Epilepsy Res. 2014 Mar;108(3):396-404. doi: 10.1016/j.eplepsyres.2014.01.010. Epub 2014 Jan 31. Epilepsy Res. 2014. PMID: 24556423

8

BBB crossing assessment and BBB crossing technologies in CNS Drug Discovery.

Gaillard PJ. Gaillard PJ. Drug Discov Today Technol. 2016 Jun;20:1-3. doi: 10.1016/j.ddtec.2016.11.002. Drug Discov Today Technol. 2016. PMID: 27986217 No abstract available.

9

Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood-brain barrier in rats.

Rip J, Chen L, Hartman R, van den Heuvel A, Reijerkerk A, van Kregten J, van der Boom B, Appeldoorn C, de Boer M, Maussang D, de Lange EC, Gaillard PJ. Rip J, et al. J Drug Target. 2014 Jun;22(5):460-7. doi: 10.3109/1061186X.2014.888070. Epub 2014 Feb 14. J Drug Target. 2014. PMID: 24524555 Free PMC article.

10

Glucocorticoid and type 1 interferon interactions at the blood-brain barrier: relevance for drug therapies for multiple sclerosis.

Gaillard PJ, van Der Meide PH, de Boer AG, Breimer DD. Gaillard PJ, et al. Neuroreport. 2001 Jul 20;12(10):2189-93. doi: 10.1097/00001756-200107200-00029. Neuroreport. 2001. PMID: 11447332

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