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Page 1
Patient-reported adverse effects of high-dose intravenous methylprednisolone treatment: a prospective web-based multi-center study in multiple sclerosis patients with a relapse.
Jongen PJ, Stavrakaki I, Voet B, Hoogervorst E, van Munster E, Linssen WH, Sinnige LG, Verhagen WI, Visser LH, van der Kruijk R, Verheul F, Boringa J, Heerings M, Gladdines W, Lönnqvist F, Gaillard P. Jongen PJ, et al. Among authors: gladdines w. J Neurol. 2016 Aug;263(8):1641-51. doi: 10.1007/s00415-016-8183-3. Epub 2016 Jun 7. J Neurol. 2016. PMID: 27272956 Free PMC article.
Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study.
Kanhai KMS, Zuiker RGJA, Stavrakaki I, Gladdines W, Gaillard PJ, Klaassen ES, Groeneveld GJ. Kanhai KMS, et al. Among authors: gladdines w. Br J Clin Pharmacol. 2018 May;84(5):1020-1028. doi: 10.1111/bcp.13525. Epub 2018 Mar 9. Br J Clin Pharmacol. 2018. PMID: 29385232 Free PMC article. Clinical Trial.
Glutathione PEGylated liposomal methylprednisolone (2B3-201) attenuates CNS inflammation and degeneration in murine myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis.
Lee DH, Rötger C, Appeldoorn CC, Reijerkerk A, Gladdines W, Gaillard PJ, Linker RA. Lee DH, et al. Among authors: gladdines w. J Neuroimmunol. 2014 Sep 15;274(1-2):96-101. doi: 10.1016/j.jneuroim.2014.06.025. Epub 2014 Jul 6. J Neuroimmunol. 2014. PMID: 25037177
Enhanced doxorubicin delivery to the brain administered through glutathione PEGylated liposomal doxorubicin (2B3-101) as compared with generic Caelyx,(®)/Doxil(®)--a cerebral open flow microperfusion pilot study.
Birngruber T, Raml R, Gladdines W, Gatschelhofer C, Gander E, Ghosh A, Kroath T, Gaillard PJ, Pieber TR, Sinner F. Birngruber T, et al. Among authors: gladdines w. J Pharm Sci. 2014 Jul;103(7):1945-1948. doi: 10.1002/jps.23994. Epub 2014 May 6. J Pharm Sci. 2014. PMID: 24801480
High-performance liquid chromatography of the neuroactive steroids alphaxalone and pregnanolone in plasma using dansyl hydrazine as fluorescent label: application to a pharmacokinetic-pharmacodynamic study in rats.
Visser SA, Smulders CJ, Gladdines WW, Irth H, van der Graaf PH, Danhof M. Visser SA, et al. Among authors: gladdines ww. J Chromatogr B Biomed Sci Appl. 2000 Aug 18;745(2):357-63. doi: 10.1016/s0378-4347(00)00296-6. J Chromatogr B Biomed Sci Appl. 2000. PMID: 11043754