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Page 1
Methionine excess in diet induces acute lethal hepatitis in mice lacking cystathionine γ-lyase, an animal model of cystathioninuria.
Yamada H, Akahoshi N, Kamata S, Hagiya Y, Hishiki T, Nagahata Y, Matsuura T, Takano N, Mori M, Ishizaki Y, Izumi T, Kumagai Y, Kasahara T, Suematsu M, Ishii I. Yamada H, et al. Among authors: ishii i. Free Radic Biol Med. 2012 May 1;52(9):1716-26. doi: 10.1016/j.freeradbiomed.2012.02.033. Epub 2012 Mar 3. Free Radic Biol Med. 2012. PMID: 22387178
Hyperhomocysteinemia abrogates fasting-induced cardioprotection against ischemia/reperfusion by limiting bioavailability of hydrogen sulfide anions.
Nakano S, Ishii I, Shinmura K, Tamaki K, Hishiki T, Akahoshi N, Ida T, Nakanishi T, Kamata S, Kumagai Y, Akaike T, Fukuda K, Sano M, Suematsu M. Nakano S, et al. Among authors: ishii i. J Mol Med (Berl). 2015 Aug;93(8):879-89. doi: 10.1007/s00109-015-1271-5. Epub 2015 Mar 6. J Mol Med (Berl). 2015. PMID: 25740079
The H2S-generating enzymes cystathionine β-synthase and cystathionine γ-lyase play a role in vascular development during normal lung alveolarization.
Madurga A, Golec A, Pozarska A, Ishii I, Mižíková I, Nardiello C, Vadász I, Herold S, Mayer K, Reichenberger F, Fehrenbach H, Seeger W, Morty RE. Madurga A, et al. Among authors: ishii i. Am J Physiol Lung Cell Mol Physiol. 2015 Oct 1;309(7):L710-24. doi: 10.1152/ajplung.00134.2015. Epub 2015 Jul 31. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 26232299 Free article.
Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation.
Wedmann R, Onderka C, Wei S, Szijártó IA, Miljkovic JL, Mitrovic A, Lange M, Savitsky S, Yadav PK, Torregrossa R, Harrer EG, Harrer T, Ishii I, Gollasch M, Wood ME, Galardon E, Xian M, Whiteman M, Banerjee R, Filipovic MR. Wedmann R, et al. Among authors: ishii i. Chem Sci. 2016 May 25;7(5):3414-3426. doi: 10.1039/c5sc04818d. Epub 2016 Feb 19. Chem Sci. 2016. PMID: 27170841 Free PMC article.
Cystathionine γ-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood Pressure.
Szijártó IA, Markó L, Filipovic MR, Miljkovic JL, Tabeling C, Tsvetkov D, Wang N, Rabelo LA, Witzenrath M, Diedrich A, Tank J, Akahoshi N, Kamata S, Ishii I, Gollasch M. Szijártó IA, et al. Among authors: ishii i. Hypertension. 2018 Jun;71(6):1210-1217. doi: 10.1161/HYPERTENSIONAHA.117.10562. Epub 2018 Apr 30. Hypertension. 2018. PMID: 29712741
293 results