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Preliminary structure-activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains.
Onajole OK, Pieroni M, Tipparaju SK, Lun S, Stec J, Chen G, Gunosewoyo H, Guo H, Ammerman NC, Bishai WR, Kozikowski AP. Onajole OK, et al. J Med Chem. 2013 May 23;56(10):4093-103. doi: 10.1021/jm4003878. Epub 2013 May 3. J Med Chem. 2013. PMID: 23611124
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4β2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
Zhang HK, Yu LF, Eaton JB, Whiteaker P, Onajole OK, Hanania T, Brunner D, Lukas RJ, Kozikowski AP. Zhang HK, et al. Among authors: onajole ok. J Med Chem. 2013 Jul 11;56(13):5495-504. doi: 10.1021/jm400510u. Epub 2013 Jun 26. J Med Chem. 2013. PMID: 23734673 Free PMC article.
Optimization of 2-phenylcyclopropylmethylamines as selective serotonin 2C receptor agonists and their evaluation as potential antipsychotic agents.
Cheng J, Giguère PM, Onajole OK, Lv W, Gaisin A, Gunosewoyo H, Schmerberg CM, Pogorelov VM, Rodriguiz RM, Vistoli G, Wetsel WC, Roth BL, Kozikowski AP. Cheng J, et al. Among authors: onajole ok. J Med Chem. 2015 Feb 26;58(4):1992-2002. doi: 10.1021/jm5019274. Epub 2015 Feb 10. J Med Chem. 2015. PMID: 25633969 Free PMC article.
Advancing the Therapeutic Potential of Indoleamides for Tuberculosis.
Lun S, Tasneen R, Chaira T, Stec J, Onajole OK, Yang TJ, Cooper CB, Mdluli K, Converse PJ, Nuermberger EL, Raj VS, Kozikowski A, Bishai WR. Lun S, et al. Among authors: onajole ok. Antimicrob Agents Chemother. 2019 Jun 24;63(7):e00343-19. doi: 10.1128/AAC.00343-19. Print 2019 Jul. Antimicrob Agents Chemother. 2019. PMID: 31010860 Free PMC article.
The preclinical candidate indole-2-carboxamide improves immune responses to Mycobacterium tuberculosis infection in healthy subjects and individuals with type 2 diabetes.
Cao R, Islamoglu H, Teskey G, Gyurjian K, Abrahem R, Onajole OK, Lun S, Bishai W, Kozikowski AP, Fraix MP, Sathananthan A, Zhong L, Stec J, Venketaraman V. Cao R, et al. Among authors: onajole ok. Int Microbiol. 2020 May;23(2):161-170. doi: 10.1007/s10123-019-00086-0. Epub 2019 Jun 19. Int Microbiol. 2020. PMID: 31218537
29 results