Zhang Z - Search Results

1

Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis.

Vidadala RS, Rivas KL, Ojo KK, Hulverson MA, Zambriski JA, Bruzual I, Schultz TL, Huang W, Zhang Z, Scheele S, DeRocher AE, Choi R, Barrett LK, Siddaramaiah LK, Hol WG, Fan E, Merritt EA, Parsons M, Freiberg G, Marsh K, Kempf DJ, Carruthers VB, Isoherranen N, Doggett JS, Van Voorhis WC, Maly DJ. Vidadala RS, et al. Among authors: zhang z. J Med Chem. 2016 Jul 14;59(13):6531-46. doi: 10.1021/acs.jmedchem.6b00760. Epub 2016 Jul 1. J Med Chem. 2016. PMID: 27309760 Free PMC article.

2

Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.

Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WG, Fan E. Merritt EA, et al. Among authors: zhang z. J Am Chem Soc. 2002 Jul 31;124(30):8818-24. doi: 10.1021/ja0202560. J Am Chem Soc. 2002. PMID: 12137534

3

Solution and crystallographic studies of branched multivalent ligands that inhibit the receptor-binding of cholera toxin.

Zhang Z, Merritt EA, Ahn M, Roach C, Hou Z, Verlinde CL, Hol WG, Fan E. Zhang Z, et al. J Am Chem Soc. 2002 Nov 6;124(44):12991-8. doi: 10.1021/ja027584k. J Am Chem Soc. 2002. PMID: 12405825

4

TFA-sensitive arylsulfonylthiourea-assisted synthesis of N,N'-substituted guanidines.

Li J, Zhang G, Zhang Z, Fan E. Li J, et al. Among authors: zhang g, zhang z. J Org Chem. 2003 Feb 21;68(4):1611-4. doi: 10.1021/jo026807m. J Org Chem. 2003. PMID: 12585918

5

Modular synthesis and study of multivalent carbohydrate ligands with long and flexible linkers.

Zhang Z, Fan E. Zhang Z, et al. Methods Enzymol. 2003;362:209-18. doi: 10.1016/S0076-6879(03)01014-0. Methods Enzymol. 2003. PMID: 12968365 No abstract available.

6

Solution- and solid-phase syntheses of guanidine-bridged, water-soluble linkers for multivalent ligand design.

Zhang Z, Pickens JC, Hol WG, Fan E. Zhang Z, et al. Org Lett. 2004 Apr 29;6(9):1377-80. doi: 10.1021/ol049835v. Org Lett. 2004. PMID: 15101746

7

Nonspanning bivalent ligands as improved surface receptor binding inhibitors of the cholera toxin B pentamer.

Pickens JC, Mitchell DD, Liu J, Tan X, Zhang Z, Verlinde CL, Hol WG, Fan E. Pickens JC, et al. Among authors: zhang z. Chem Biol. 2004 Sep;11(9):1205-15. doi: 10.1016/j.chembiol.2004.06.008. Chem Biol. 2004. PMID: 15380181

8

Large cyclic peptides as cores of multivalent ligands: application to inhibitors of receptor binding by cholera toxin.

Zhang Z, Liu J, Verlinde CL, Hol WG, Fan E. Zhang Z, et al. J Org Chem. 2004 Oct 29;69(22):7737-40. doi: 10.1021/jo0489770. J Org Chem. 2004. PMID: 15498005

9

Structural biology and structure-based inhibitor design of cholera toxin and heat-labile enterotoxin.

Fan E, O'Neal CJ, Mitchell DD, Robien MA, Zhang Z, Pickens JC, Tan XJ, Korotkov K, Roach C, Krumm B, Verlinde CL, Merritt EA, Hol WG. Fan E, et al. Among authors: zhang z. Int J Med Microbiol. 2004 Oct;294(4):217-23. doi: 10.1016/j.ijmm.2004.07.002. Int J Med Microbiol. 2004. PMID: 15532979 Review.

10

Protein heterodimerization through ligand-bridged multivalent pre-organization: enhancing ligand binding toward both protein targets.

Liu J, Zhang Z, Tan X, Hol WG, Verlinde CL, Fan E. Liu J, et al. Among authors: zhang z. J Am Chem Soc. 2005 Feb 23;127(7):2044-5. doi: 10.1021/ja043817r. J Am Chem Soc. 2005. PMID: 15713072

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